Document Detail

Environmental tobacco smoke and carotid arterial stiffness.
MedLine Citation:
PMID:  12855214     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although active smoking acutely increases arterial stiffness, the association between arterial stiffness and chronic exposure to environmental tobacco smoke (ETS) has not been evaluated. We used baseline data from the Vitamin E Atherosclerosis Prevention Study to evaluate the association between ETS exposure and arterial stiffness among 227 healthy adult nonsmokers. METHODS: B-mode ultrasonograms of the common carotid artery were used to compute the carotid arterial wall stiffness index beta. Beta was compared by the number of sources and daily hours of ETS exposure. RESULTS: The carotid stiffness index beta was positively associated with age, body mass index (BMI), fasting glucose, and common carotid artery intima-media thickness (IMT). In the total sample, beta was not related to the number of ETS exposure sources. The carotid stiffness index beta increased with number of sources and daily hours of ETS in subjects with BMI > or =27.1 kg/m2 and IMT > or =0.707 mm. The association was not apparent in subjects with lower BMI or IMT (for number of ETS sources, interaction P values=0.006 and 0.01, respectively). For number of ETS sources, but not hours of exposure, positive associations were apparent among females (but not males) and among subjects > or =55 years old (but not younger subjects). CONCLUSIONS: These data indicate that arterial stiffness is adversely associated with ETS in a dose-dependent manner among individuals with higher BMI and greater carotid artery IMT.
Wendy J Mack; Talat Islam; Zenaida Lee; Robert H Selzer; Howard N Hodis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Preventive medicine     Volume:  37     ISSN:  0091-7435     ISO Abbreviation:  Prev Med     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-11     Completed Date:  2003-11-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Department of Preventive Medicine and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
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MeSH Terms
Carotid Artery Diseases / etiology*
Carotid Artery, Common / physiopathology*,  ultrasonography
Clinical Trials as Topic
Middle Aged
Risk Factors
Tobacco Smoke Pollution / adverse effects*
Grant Support
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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