Document Detail

Environmental risk factors of cancer and their primary prevention.
MedLine Citation:
PMID:  8459368     Owner:  NLM     Status:  MEDLINE    
The evaluation of the influence of different environmental carcinogenic factors requires interdisciplinary cooperation. Related studies include epidemiological surveys and air, water and soil, chemical, toxicological, and microbiological analyses, supplemented by experimental verification of suspected ecological pathogens and cofactors. A balance of carcinogens and protective agents in the external environment and in the human body is recommended for an ecologically oriented prevention. Toxicological control of the food chain using modern technology (Proton-induced X-ray emission (PIXE), nuclear activation analysis, and induced coupled plasma) should be integrated with microanalyses at the cellular level (by X-ray scanning electron microscopy, nuclear magnetic response, PIXE, and spontaneous and delayed chemiluminescence for balance of free-radicals and their scavengers). A pilot cross-disciplinary study conducted in the area of a "cluster" of human neoplasms and cattle leukemia, in comparison with control villages in Poland, showed an excess in Pb, Hg, Ni, Rb, K, Mn, Cr, and Zn, accompanied by a nutritional deficiency in Mg, Ca, Fe, Co, and Se in the food chain of the "cluster." The living and breeding houses in this area were significantly more contaminated with the toxicogenic molds Aspergillus flavus and Penicillium meleagrinum and by nitrate and nitrite in the drinking water. Our experiments showed that selenium deficiency stimulated the growth of fungi and some bacteria and increased the immunosuppressive and teratogenic effects of aflatoxin B1. New methods of protection of the indoor environment against microbiological contamination and laser-related biotechnology for nutritional prevention of selenium deficiency and associated risk of neoplasms have been introduced. Primary prevention requires a large scale application of highly sensitive methods for early detection of risk factors in the environment, food, water, and at the personal level, as well as education of the society and an integrated common corrective action.
J W Dobrowolski; B Smyk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  12     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:    1993 Jan-Mar
Date Detail:
Created Date:  1993-04-26     Completed Date:  1993-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-7     Citation Subset:  IM    
Institute of Management and Protection of the Environment, Polish Academy of Sciences, Krakow.
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MeSH Terms
Air Pollution
Environmental Exposure*
Food Supply
Fungi / isolation & purification
Health Education
Neoplasms / chemically induced,  prevention & control*
Risk Factors
Selenium / physiology
Soil Pollutants
Water Pollutants
Reg. No./Substance:
0/Carcinogens; 0/Soil Pollutants; 0/Water Pollutants; 7782-49-2/Selenium

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