Document Detail


Environmental regulation of placental phenotype: implications for fetal growth.
MedLine Citation:
PMID:  22394720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental conditions during pregnancy determine birthweight, neonatal viability and adult phenotype in human and other animals. In part, these effects may be mediated by the placenta, the principal source of nutrients for fetal development. However, little is known about the environmental regulation of placental phenotype. Generally, placental weight is reduced during suboptimal conditions like maternal malnutrition or hypoxaemia but compensatory adaptations can occur in placental nutrient transport capacity to help maintain fetal growth. In vivo studies show that transplacental glucose and amino acid transfer adapt to the prevailing conditions induced by manipulating maternal calorie intake, dietary composition and hormone exposure. These adaptations are due to changes in placental morphology, metabolism and/or abundance of specific nutrient transporters. This review examines environmental programming of placental phenotype with particular emphasis on placental nutrient transport capacity and its implications for fetal growth, mainly in rodents. It also considers the systemic, cellular and molecular mechanisms involved in signalling environmental cues to the placenta. Ultimately, the ability of the placenta to balance the competing interests of mother and fetus in resource allocation may determine not only the success of pregnancy in producing viable neonates but also the long-term health of the offspring.
Authors:
O R Vaughan; A N Sferruzzi-Perri; P M Coan; A L Fowden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  24     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-08-14     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  80-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport / physiology
Cellular Microenvironment / physiology*
Epigenesis, Genetic / physiology
Female
Fetal Development / physiology*
Humans
Mice
Models, Animal
Phenotype*
Placenta / anatomy & histology,  physiology*
Pregnancy
Rats
Ruminants
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
BB/I011773/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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