Document Detail

Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens.
MedLine Citation:
PMID:  15245359     Owner:  NLM     Status:  MEDLINE    
Indoor allergens represent an important precipitating factor for both asthma and atopic eczema dermatitis syndromes (AEDS). There is also accumulating evidence that sensitization to those allergens is associated with the onset of atopic disorders. Patients with AEDS present aeroallergen-specific T-cell responses associated with worsening of symptoms when exposed to specific aeroallergens. Furthermore, application of indoor allergens to the skin of patient with AEDS induces a local eczematous response in one-third of these patients. Exposure to high concentrations of mite allergens in early infancy have been demonstrated to be a risk factor for developing atopic dermatitis during the first 3 years of life. Moreover, a clear dose-response relationship has been documented between mite exposure and disease activity. Primary prevention of AEDS by avoiding indoor allergen exposure has been proved to be effective only when allergenic foods have also been avoided. Mite allergen avoidance in infants with AEDS and food allergy may however, prevent mite sensitization and the onset of asthma. Indoor allergen avoidance has been demonstrated to be effective in the majority of studies performed in patients with established AEDS. Negative results may be explained either by individual susceptibility variation, by long duration of disease with the consequent irreversible pathological changes in the target tissue or by exposure to allergens outside the house. Education of the patients and public consciousness of the problems are crucial for the efficacy of indoor allergen avoidance in allergic diseases.
C Capristo; I Romei; A L Boner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Allergy     Volume:  59 Suppl 78     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-12     Completed Date:  2004-11-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Blackwell Munksgaard
Department of Pediatris Second University of Naples, Italy.
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MeSH Terms
Air Pollution, Indoor* / adverse effects
Asthma / diagnosis,  etiology,  prevention & control*
Dermatitis, Atopic / diagnosis,  etiology,  prevention & control*
Risk Factors
Skin Tests
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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