Document Detail

Environmental factors and leukaemia.
MedLine Citation:
PMID:  3903369     Owner:  NLM     Status:  MEDLINE    
Investigations on the association between environmental hazards and the development of various types of leukaemia are reviewed. Regarding acute non-lymphocytic leukaemia (ANLL) exposure to ionizing radiation is a well-documented risk factor. According to several recent studies exposure to strong electromagnetic fields may be suspected to be of etiologic importance for ANLL. There is evidence that occupational handling of benzene is a risk factor and other organic solvents may also be leukaemogenic. Occupational exposure to petrol products has been proposed to be a risk factor although the hazardous substances have not yet been defined. Results of cytogenetic studies in ANLL suggest that exposure to certain environmental agents may be associated with relatively specific clonal chromosome aberrations. These results are of interest because it has been proposed that chromosomal rearrangements may play a role in the activation of cellular oncogens. Exposure in utero to ionizing radiation has been proposed to be a risk factor for acute lymphocytic leukaemia (ALL) in children. Unlike ANLL there seems at present to be little evidence that ALL is related to exposure to some chemicals. Chronic myeloid leukaemia (CML) may follow exposure to high doses of ionizing radiation whereas such exposure seems to be of insignificant importance for the development of chronic lymphocytic leukaemia (CLL). According to some studies an abnormally high incidence of CLL may be found among farmers in the USA. These results have not been confirmed in Scandinavian studies. There seems to be little evidence that CML or CLL are related to occupational handling of some chemicals.(ABSTRACT TRUNCATED AT 250 WORDS)
L Brandt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medical oncology and tumor pharmacotherapy     Volume:  2     ISSN:  0736-0118     ISO Abbreviation:  Med Oncol Tumor Pharmacother     Publication Date:  1985  
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8405039     Medline TA:  Med Oncol Tumor Pharmacother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Benzene / adverse effects
Chromosome Aberrations
Electromagnetic Phenomena
Environmental Exposure*
Gasoline / adverse effects
Leukemia / etiology*
Leukemia, Lymphoid / etiology
Leukemia, Myeloid / etiology
Leukemia, Radiation-Induced / etiology
Prenatal Exposure Delayed Effects
Reg. No./Substance:
0/Gasoline; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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