Document Detail


Environmental exposure to organophosphate pesticides: Assessment of endocrine disruption and hepatotoxicity in pregnant women.
MedLine Citation:
PMID:  22494479     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In utero exposure is the first point of contact with environmental xenobiotics that may affect the maternal-placental-fetal balance. Considering that maternal pathophysiological changes affect intrauterine development, this pilot study was conducted to address how environmental exposure to organophosphate pesticides (OPs) during pregnancy may contribute to maternal endocrine disruption and disturbed hepatic function. A prospective study was carried out with pregnant women (n=97) living in a rural area of the Rio Negro province where OPs are intensively applied throughout 6 months of the year. Blood samples were obtained and biomarkers of OPs exposure (cholinesterases and β-glucuronidase), cortisol (CT) and progesterone (PG) levels, as well as glycemia, were determined. Parameters of liver injury were assayed by measuring aspartate aminotransferase (AST) and alanine aminotransferase (ALT); liver function was assayed by measuring albumin. Biomonitoring carried out during the pre-spraying period (PreS) and spraying period (SP) showed that the population studied was exposed to OPs, proven by the fact that plasma (PCh) and erythrocyte cholinesterase (AChE) decreased very significantly (p<0.01) during SP. CT values increased very significantly (p<0.01) in the first trimester of pregnancy during SP with respect to PreS. Individual values above the upper limit of the CT and PG reference range were found both in PreS and SP. This finding could be associated with changes in hormone metabolism pathways produced by OPs exposure. During the second trimester of pregnancy there were increases in ALT values and the AST/ALT ratio in SP, suggesting subclinical hepatotoxicity. In SP, glycemia was unchanged while albuminemia increased. Although anthropometric newborn parameters and pregnancy alterations were within normal values for the general population, the increase in CT in the maternal compartment may lead to impaired newborn health later in life.
Authors:
A Cecchi; M G Rovedatti; G Sabino; G G Magnarelli
Related Documents :
3455139 - In utero therapy of fetal obstructive uropathy.
479349 - Renal clearance of estriol and its conjugates in normal and abnormal pregnancies.
11929469 - Urological problems in pregnancy.
17306939 - Monitoring of cadmium toxicity in a thai population with high-level environmental expos...
11244269 - Aberrant pyramidal tract in the medial lemniscus of the human brainstem: normal distrib...
25086989 - Relationships between mental health symptoms and body mass index in women with and with...
3925839 - Successful in vitro fertilization with sperm cells from a man with immune infertility.
23756929 - Cervical cerclage for preventing preterm birth in twin pregnancies. a systematic review...
10586529 - Is angiotensinogen gene polymorphism associated with hypertension in pregnancy?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-9
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  -     ISSN:  1090-2414     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Hospital Dr. Ernesto Accame, Ing Quesnel S/N°, Allen (8328), Río Negro, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Accumulation of 20 elements in great cormorant (Phalacrocorax carbo) and its main prey, common carp ...
Next Document:  Ultrasound Appearance of Forearm Muscles in 18 Patients With Complex Regional Pain Syndrome 1 of the...