| Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort. | |
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MedLine Citation:
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PMID: 16618359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infantile atopic eczema (AE) is a risk marker for future asthma. This study assesses the contribution of modifiable exposures to infantile AE. If modifiable exposures contribute substantially to infantile AE, its prevention might be a sensible approach to asthma prevention. Pregnant women (n = 1978) were systematically recruited from maternity hospitals of the Slovak Republic; their birthed cohort of 1990 children were prospectively followed for 1 yr. Children's exposures to selected environmental and dietary factors were assessed via maternal questionnaires administered at delivery and 1 yr of age. A child was considered to have AE, based on physical examination (SCORAD index >2) or mother's report of a previous physician diagnosis. Multivariate logistic regression was used to calculate adjusted odds ratios and percent total regression scores (TRS) for each variable. At 1 yr of age 1326 (67%) of the children remained in the cohort and 207 (15.6%) developed AE. Various modifiable environmental and dietary exposures increased the likelihood of AE (ownership of cats; consumption of infant formula, eggs, and fish) while others decreased the likelihood of AE (ownership of livestock; exclusive breast feeding for > or =4 months). Overall, modifiable exposures contributed less to the TRS than did non-modifiable exposures (38% vs. 62%, respectively). The modifiable exposure category that contributed most to the TRS was infant feeding practices (27.5% TRS). Modifiable exposures -- especially those related to infant feeding practices -- significantly contribute to infantile AE, although modifiable factors contribute less overall than do non-modifiable exposures. |
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Authors:
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Anne L Dunlop; Eva Reichrtova; Luba Palcovicova; Peter Ciznar; Andrea Adamcakova-Dodd; S J Smith; Scott J N McNabb |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 17 ISSN: 0905-6157 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-18 Completed Date: 2007-03-26 Revised Date: 2008-05-28 |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: 103-11 Citation Subset: IM |
Affiliation:
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Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. amlang@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / prevention & control Cohort Studies Dermatitis, Atopic / epidemiology, etiology*, prevention & control Diet / adverse effects* Environmental Exposure / adverse effects* Female Humans Infant Logistic Models Male Multivariate Analysis Pregnancy Prevalence Prospective Studies Risk Factors Slovakia |
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