Document Detail

Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort.
MedLine Citation:
PMID:  16618359     Owner:  NLM     Status:  MEDLINE    
Infantile atopic eczema (AE) is a risk marker for future asthma. This study assesses the contribution of modifiable exposures to infantile AE. If modifiable exposures contribute substantially to infantile AE, its prevention might be a sensible approach to asthma prevention. Pregnant women (n = 1978) were systematically recruited from maternity hospitals of the Slovak Republic; their birthed cohort of 1990 children were prospectively followed for 1 yr. Children's exposures to selected environmental and dietary factors were assessed via maternal questionnaires administered at delivery and 1 yr of age. A child was considered to have AE, based on physical examination (SCORAD index >2) or mother's report of a previous physician diagnosis. Multivariate logistic regression was used to calculate adjusted odds ratios and percent total regression scores (TRS) for each variable. At 1 yr of age 1326 (67%) of the children remained in the cohort and 207 (15.6%) developed AE. Various modifiable environmental and dietary exposures increased the likelihood of AE (ownership of cats; consumption of infant formula, eggs, and fish) while others decreased the likelihood of AE (ownership of livestock; exclusive breast feeding for > or =4 months). Overall, modifiable exposures contributed less to the TRS than did non-modifiable exposures (38% vs. 62%, respectively). The modifiable exposure category that contributed most to the TRS was infant feeding practices (27.5% TRS). Modifiable exposures -- especially those related to infant feeding practices -- significantly contribute to infantile AE, although modifiable factors contribute less overall than do non-modifiable exposures.
Anne L Dunlop; Eva Reichrtova; Luba Palcovicova; Peter Ciznar; Andrea Adamcakova-Dodd; S J Smith; Scott J N McNabb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  17     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2007-03-26     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-11     Citation Subset:  IM    
Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
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MeSH Terms
Asthma / prevention & control
Cohort Studies
Dermatitis, Atopic / epidemiology,  etiology*,  prevention & control
Diet / adverse effects*
Environmental Exposure / adverse effects*
Logistic Models
Multivariate Analysis
Prospective Studies
Risk Factors

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