Document Detail

Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms.
MedLine Citation:
PMID:  9570778     Owner:  NLM     Status:  MEDLINE    
In newly hatched Drosophila larvae, quiescent cells reenter the cell cycle in response to dietary amino acids. To understand this process, we varied larval nutrition and monitored effects on cell cycle initiation and maintenance in the mitotic neuroblasts and imaginal disc cells, as well as the endoreplicating cells in other larval tissues. After cell cycle activation, mitotic and endoreplicating cells respond differently to the withdrawal of nutrition: mitotic cells continue to proliferate in a nutrition-independent manner, while most endoreplicating cells reenter a quiescent state. We also show that ectopic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplicating cells, but not quiescent imaginal neuroblasts, into S-phase. Conversely, we demonstrate that quiescent imaginal neuroblasts, but not quiescent endoreplicating cells, can be induced to enter the cell cycle when co-cultured with larval fat body in vitro. These results demonstrate a fundamental difference in the control of cell cycle activation and maintenance in these two cell types, and imply the existence of a novel mitogen generated by the larval fat body in response to nutrition.
J S Britton; B A Edgar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-14     Completed Date:  1998-07-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2149-58     Citation Subset:  IM    
Molecular and Cellular Biology Program and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.
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MeSH Terms
Amino Acids / pharmacology*
Animal Nutritional Physiological Phenomena
Cell Cycle / drug effects
Cell Cycle Proteins / metabolism
Cells, Cultured / drug effects
Culture Techniques
DNA Replication / drug effects
Drosophila / cytology*,  drug effects
Drosophila Proteins*
Fat Body / secretion
Glycoproteins / metabolism
Insect Proteins / metabolism
Larva / cytology,  drug effects
Mitogens / pharmacology*
Models, Biological
Neurons / cytology
Signal Transduction
Stem Cells
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Cell Cycle Proteins; 0/Drosophila Proteins; 0/Glycoproteins; 0/Insect Proteins; 0/Mitogens; 0/anachronism protein, Drosophila

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