| Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. | |
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MedLine Citation:
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PMID: 9570778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In newly hatched Drosophila larvae, quiescent cells reenter the cell cycle in response to dietary amino acids. To understand this process, we varied larval nutrition and monitored effects on cell cycle initiation and maintenance in the mitotic neuroblasts and imaginal disc cells, as well as the endoreplicating cells in other larval tissues. After cell cycle activation, mitotic and endoreplicating cells respond differently to the withdrawal of nutrition: mitotic cells continue to proliferate in a nutrition-independent manner, while most endoreplicating cells reenter a quiescent state. We also show that ectopic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplicating cells, but not quiescent imaginal neuroblasts, into S-phase. Conversely, we demonstrate that quiescent imaginal neuroblasts, but not quiescent endoreplicating cells, can be induced to enter the cell cycle when co-cultured with larval fat body in vitro. These results demonstrate a fundamental difference in the control of cell cycle activation and maintenance in these two cell types, and imply the existence of a novel mitogen generated by the larval fat body in response to nutrition. |
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Authors:
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J S Britton; B A Edgar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 125 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-14 Completed Date: 1998-07-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2149-58 Citation Subset: IM |
Affiliation:
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Molecular and Cellular Biology Program and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacology* Animal Nutritional Physiological Phenomena Animals Cell Cycle / drug effects Cell Cycle Proteins / metabolism Cells, Cultured / drug effects Culture Techniques DNA Replication / drug effects Drosophila / cytology*, drug effects Drosophila Proteins* Environment Fat Body / secretion Glycoproteins / metabolism Insect Proteins / metabolism Larva / cytology, drug effects Mitogens / pharmacology* Models, Biological Neurons / cytology Signal Transduction Stem Cells |
| Grant Support | |
ID/Acronym/Agency:
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GM51186/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Cell Cycle Proteins; 0/Drosophila Proteins; 0/Glycoproteins; 0/Insect Proteins; 0/Mitogens; 0/anachronism protein, Drosophila |
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