Document Detail


Environmental conditioning in the control of macrophage thrombospondin-1 production.
MedLine Citation:
PMID:  22803005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated signals. Their production of TSP-1 is regulated by environmental signals that establish a threshold for the level of protein secretion that can be induced by LPS stimulation. Th1 and Th2 cytokines raise this threshold which leads to less TSP-1 production, while signals that promote the generation of regulatory macrophages lower it. TSP-1 plays no direct role in the regulation of its own secretion. In vivo in uveitis, in the presence of TLR-4 ligands, TSP-1 is initially produced by recruited macrophages but this decreases in the presence of inflammatory cytokines. The adaptive immune system therefore plays a dominant role in regulating TSP-1 production in the target organ during acute inflammation.
Authors:
Jezrom B Fordham; Jing Hua; Sarah R Morwood; Lauren P Schewitz-Bowers; David A Copland; Andrew D Dick; Lindsay B Nicholson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-16
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-17     Completed Date:  2013-03-17     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  512     Citation Subset:  IM    
Affiliation:
School of Clinical Sciences, University of Bristol, Bristol, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology
Animals
Bone Marrow Cells / drug effects,  immunology,  metabolism
Cell Communication / immunology
Cytokines / pharmacology
Dinoprostone / pharmacology
Lipopolysaccharides / immunology
Lymphocyte Activation / immunology
Macrophages / drug effects,  immunology,  metabolism*
Mice
Mice, Knockout
Peritoneal Cavity
Th1 Cells / immunology
Th2 Cells / immunology
Thrombospondin 1 / biosynthesis*
Toll-Like Receptor 4 / metabolism
Uveitis / genetics,  immunology,  metabolism
Grant Support
ID/Acronym/Agency:
//Medical Research Council
Chemical
Reg. No./Substance:
0/Cytokines; 0/Lipopolysaccharides; 0/Thrombospondin 1; 0/Toll-Like Receptor 4; 363-24-6/Dinoprostone; 58-61-7/Adenosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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