Document Detail


Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna.
MedLine Citation:
PMID:  11857462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of ecdysteroids in crustacean embryo development and the susceptibility of the developing embryo to the antiecdysteroidal properties of an environmental chemical were evaluated. The agricultural fungicide fenarimol was shown to exhibit antiecdysteroidal activity to the crustacean Daphnia magna by lowering endogenous ecdysone levels and delaying molting in a concentration-dependent fashion that was mitigated by co-exposure to exogenous 20-hydroxyecdysone. Exposure of either gravid maternal organisms or isolated embryos to fenarimol resulted in embryo abnormalities ranging from early partial developmental arrest to incomplete development of antennae and shell spines. Developmental abnormalities were associated with suppressed ecdysone levels in the embryos and the abnormalities could be prevented by co-exposure to 20-hydroxyecdysone. Developmental abnormalities caused by the antiecdysteroid were associated with reduced fecundity of the parental organisms. These results demonstrate that ecdysteroids are critical to normal crustacean embryo development and environmental antiecdysteroids can disrupt normal embryo development and compromise the production of viable offspring. Antiecdysteroidal activity may provide a means by which environmental chemicals impact crustacean species while not affecting vertebrates.
Authors:
Xueyan Mu; Gerald A LeBlanc
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  292     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-21     Completed Date:  2002-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Congenital Abnormalities / physiopathology,  veterinary
Daphnia / embryology*
Ecdysone / antagonists & inhibitors*
Female
Fertility
Fungicides, Industrial / pharmacology
Molting / physiology*
Pyrimidines / pharmacology
Chemical
Reg. No./Substance:
0/Fungicides, Industrial; 0/Pyrimidines; 3604-87-3/Ecdysone; 60168-88-9/fenarimol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of melatonin in photoperiodic time measurement in the migratory redheaded bunting (Emberiza bru...
Next Document:  Catecholamines are present in larval Xenopus laevis: a potential source for cardiac control.