Document Detail


Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity.
MedLine Citation:
PMID:  23132119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings.
STUDY DESIGN: A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, non-malformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation.
RESULTS: Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders.
CONCLUSION: Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.
Authors:
Hugo B Krupitzki; Enrique C Gadow; Juan A Gili; Belén Comas; Viviana R Cosentino; César Saleme; Jeffrey C Murray; Jorge S Lopez Camelo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-06
Journal Detail:
Title:  American journal of perinatology     Volume:  30     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2013-10-22     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-61     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Cluster Analysis
Female
Fetal Membranes, Premature Rupture / epidemiology
Humans
Infant, Newborn
Life Style
Male
Pregnancy
Pregnancy Complications / epidemiology
Pregnancy Outcome
Premature Birth / epidemiology*,  genetics,  physiopathology
Recurrence
Retrospective Studies
Risk Factors
Stillbirth / epidemiology
Grant Support
ID/Acronym/Agency:
1R01 HD-529/HD/NICHD NIH HHS; P30 ES005605/ES/NIEHS NIH HHS; R01 HD052953/HD/NICHD NIH HHS
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