| Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure. | |
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MedLine Citation:
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PMID: 20569242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Alcohol abuse leads to marked disruptions of circadian rhythms, and these disturbances in themselves can increase the drive to drink. Circadian clock timing is regulated by light, as well as by nonphotic influences such as food, social interactions, and wheel running. We previously reported that alcohol markedly disrupts photic and nonphotic modes of circadian rhythm regulation in Syrian hamsters. As an extension of this work, we characterize the hedonic interrelationship between wheel running and ethanol (EtOH) intake and the effects of environmental circadian disruption (long-term exposure to constant light [LL]) on the drive to drink. METHODS: First, we tested the effect of wheel running on chronic free-choice consumption of a 20% (v/v) EtOH solution and water. Second, the effect of this alcohol drinking on wheel running in alcohol-naive animals was investigated. Third, we assessed the influence of LL, known to suppress locomotor activity and cause circadian rhythm disruption, on EtOH consumption and wheel-running behavior. RESULTS: Inhibitory effects of wheel running on EtOH intake and vice versa were observed. Exposure to LL, while not affecting EtOH intake, induced rhythm splitting in 75% of the animals. Notably, the splitting phenotype was associated with lower levels of EtOH consumption and preference prior to, and throughout, the period of LL exposure. CONCLUSIONS: These results are evidence that exercise may offer an efficacious clinical approach to reducing EtOH intake. Also, predisposition for light-induced (or other) forms of circadian disruption may modulate the drive to drink. |
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Authors:
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Steven B Hammer; Christina L Ruby; Allison J Brager; Rebecca A Prosser; John David Glass |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-21 |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 34 ISSN: 1530-0277 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2011-01-20 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: England |
Other Details:
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Languages: eng Pagination: 1651-8 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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psychology* Animals Choice Behavior Chronobiology Disorders / psychology* Cricetinae Light Mesocricetus Motor Activity / drug effects* Photoperiod* |
| Grant Support | |
ID/Acronym/Agency:
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AA-015948/AA/NIAAA NIH HHS; R01 AA017898-02/AA/NIAAA NIH HHS; R21 AA015948-02/AA/NIAAA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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