| Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. | |
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MedLine Citation:
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PMID: 19879291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Manganese (Mn) is an essential element, yet is neurotoxic in excess. The majority of Mn research has been conducted on occupationally exposed adults with few studies focused on an environmentally exposed population. Marietta, OH is home to one of the largest airborne Mn emission sources in the United States, a ferromanganese refinery. In preparation for a community-based participatory research study, a preliminary pilot study was initiated to characterize the community's exposure to Mn in ambient air and to evaluate the relationship between biological indices of Mn exposure and genes associated with Mn metabolism in Marietta area residents. Participants in the pilot study were recruited through newspaper advertisement, fliers and direct mailing. Exposure to ambient Mn was estimated using an air pollution dispersion model, AERMOD. A total of 141 residents participated in the pilot study ranging in age from 2 to 81 years. Estimated annual average ambient air Mn concentrations in the study area obtained from AERMOD varied from 0.02 to 2.61 microg/m(3). Mean blood and hair Mn values were 9.12 microg/L (SD 3.90) and 5.80 microg/g (SD 6.40 microg/g), respectively and were significantly correlated (r=0.30, p<0.01). Blood and hair Mn was significantly associated within families (r=0.27, p=<0.02 and r=0.43, p<0.01), respectively. The relationship between hair Mn and estimated ambient air Mn became significant when genes for iron metabolism were included in linear models. The preliminary ambient air and biological concentrations of Mn found in this population demonstrate the need for further research into potential health effects. |
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Authors:
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Erin N Haynes; Pamela Heckel; Patrick Ryan; Sandy Roda; Yuet-Kin Leung; Kelly Sebastian; Paul Succop |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-29 |
Journal Detail:
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Title: Neurotoxicology Volume: 31 ISSN: 1872-9711 ISO Abbreviation: Neurotoxicology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-21 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 468-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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University of Cincinnati, Department of Environmental Health, USA. Erin.Haynes@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antigens, Surface / genetics Child Child, Preschool Community-Based Participatory Research* Environmental Exposure* / statistics & numerical data Female Hair / metabolism Hemochromatosis / genetics Humans Infant Male Manganese / blood Manganese Poisoning / blood, epidemiology*, genetics Middle Aged Ohio / epidemiology Pilot Projects Polymorphism, Single Nucleotide / genetics Statistics as Topic Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R21ES013524-02R21/ES/NIEHS NIH HHS; 5T32ES10957/ES/NIEHS NIH HHS; P30 ES006096-16A19020/ES/NIEHS NIH HHS; P30-ES06096/ES/NIEHS NIH HHS; R01 ES016531-02/ES/NIEHS NIH HHS; R01 ES016531-05/ES/NIEHS NIH HHS; R01ES016531/ES/NIEHS NIH HHS; R21 ES013524-01/ES/NIEHS NIH HHS; T32 ES010957-09/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Surface; 0/H63 antigen; 7439-96-5/Manganese |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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