Document Detail

Environmental and Genetic Determinants of Vitamin D Insufficiency in 12-month-old Infants.
MedLine Citation:
PMID:  25174667     Owner:  NLM     Status:  Publisher    
To investigate the relationship between genetic and environmental exposure and vitamin D status at age one, stratified by ethnicityThis study included56312-month-old infants in the HealthNuts population-based study. DNA from participants' blood samples was genotyped using SequenomMassARRAY MALDI-TOF system on 28 single nucleotide polymorphisms (SNPs) in six genes. Using logistic regression, we examined associations between environmental exposure and SNPs in vitamin D pathway and filaggringenes and vitamin D insufficiency (VDI). VDI, defined as serum 25-hydroxyvitamin D3(25(OH)D3) level ≤ 50nmol/L, was measured using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Infants were stratified by ethnicity determined by parent's country of birth. Infants formula fed at 12 months were associated with reduced odds of VDI compared to infants with no current formula use at 12 months. This association differed by ethnicity (Pinteraction=0.01). The odds ratio (OR) of VDI was 0.29forCaucasian infants (95% CI, 0.18-0.47) and 0.04for Asian infants (95% CI, 0.006-0.23). Maternal vitamin D supplementation during pregnancy and/or breastfeeding were associated with increased odds of infants being VDI (OR, 2.39; 95% CI, 1.11-5.18 and OR, 2.5; 95% CI, 1.20-5.24 respectively). Presence of a minor allele for any GC SNP (rs17467825, rs1155563, rs2282679, rs3755967, rs4588, rs7041) was associated with increased odds of VDI. Caucasian infants homozygous (AA) for rs4588 had an OR of 2.49 of being associated with VDI (95% CI, 1.19-5.18).In a country without routine infant vitamin D supplementation or food chain fortification, formula use is strongly associated with a reduced risk of VDI regardless of ethnicity. There was borderline significance for an association between filaggrin mutations and VDI. However, polymorphisms in vitamin D pathway related genes were associated with increased likelihood of being VDI in infancy.
Noor H A Suaini; Jennifer J Koplin; Justine A Ellis; Rachel L Peters; Anne-Louise Ponsonby; Shyamali C Dharmage; Melanie C Matheson; Melissa Wake; Mary Panjari; Hern-Tze Tina Tan; Pamela E Martin; Angela Pezic; Adrian J Lowe; David Martino; Lyle C Gurrin; Peter J Vuillermin; Mimi L K Tang; Katrina J Allen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-28
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  -     ISSN:  1879-1220     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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