| Environmental Enrichment can Prevent Cognitive Decline Induced by Dietary Oxidative Challenge. | |
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MedLine Citation:
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PMID: 22045493 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Alzheimer's disease encompasses multiple risk factors; convergence may be necessary for clinical manifestation. Mice received a complete diet or one lacking folate and vitamin E and containing iron as a pro-oxidant, in a standard environment (SE) or a large cage containing objects to stimulate exploration/activity (enriched environment; EE). Mice declined in maze navigation on the deficient versus complete diet in the SE but not the EE. Mice on the complete diet demonstrated superior performance in the EE versus SE. The EE reduced brain lipid and protein oxidation. These findings suggest that maintaining nutrition and activity may delay age-related cognitive decline. |
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Authors:
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Sangmook Lee; Vanessa Doulames; Michelle Donnelly; James Levasseaur; Thomas B Shea |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: - ISSN: 1875-8908 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts•Lowell, Lowell, MA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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