| Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice. | |
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MedLine Citation:
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PMID: 20707722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related changes in immunity have been shown to highly influence morbidity and mortality. The aim of the present work was to study the effects of environmental enrichment (EE) (8-16 weeks) on several functions and oxidative stress parameters of peritoneal leukocytes, previously described as health and longevity markers, in mice at different ages, namely adult (44 +/- 4 weeks), old (69 +/- 4 weeks), and very old (92 +/- 4 weeks). Mortality rates were monitored in control and enriched animals, and effects on survival of long-term exposure to EE until natural death were determined. The results showed that exposure to EE was efficient in improving the function (i.e., macrophage chemotaxis and phagocytosis, lymphocyte chemotaxis and proliferation, natural killer cell activity, interleukin-2 and tumor necrosis factor-alpha levels) and decreasing the oxidative-inflammatory stress (i.e., lowered oxidized glutathione content, xanthine oxidase activity, expression of Toll-like receptors 2 and 4 on CD4 and CD8 cells, and increased reduced glutathione and glutathione peroxidase and catalase activities) of immune cells. These positive effects of EE were especially remarkable in animals at older ages. Importantly, long-term exposure to EE from adult age and until natural death stands out as a useful strategy to extend longevity. Thus, the present work confirms the importance of maintaining active mental and/or physical activity aiming to improve quality of life in terms of immunity, and demonstrates that this active life must be initiated at early stages of the aging process and preserved until death to improve life span. |
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Authors:
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Lorena Arranz; Nuria M De Castro; Isabel Baeza; Ianire Maté; Maria Paz Viveros; Mónica De la Fuente |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rejuvenation research Volume: 13 ISSN: 1557-8577 ISO Abbreviation: Rejuvenation Res Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-02 Revised Date: 2010-12-28 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 415-28 Citation Subset: IM |
Affiliation:
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Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Madrid Complutense University, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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immunology* Animals Chemotaxis, Leukocyte Female Glutathione / metabolism Interleukin-2 / metabolism Killer Cells, Natural / immunology Longevity* Mice Mice, Inbred ICR Oxidative Stress Phagocytosis Toll-Like Receptors / blood Tumor Necrosis Factor-alpha / metabolism Xanthine Oxidase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2; 0/Toll-Like Receptors; 0/Tumor Necrosis Factor-alpha; 70-18-8/Glutathione; EC 1.17.3.2/Xanthine Oxidase |
| Comments/Corrections | |
Erratum In:
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Rejuvenation Res. 2010 Oct;13(5):627 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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