Document Detail


Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.
MedLine Citation:
PMID:  23042574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A light in the dark: the fermentation products of the polyketide synthase CalE8 (without its cognate thioesterase) were identified and gave some insight into the elusive early steps of calicheamicin biosynthesis. Fermentation in either the light or dark resulted in different proportions of a new octaketide and led to an updated mechanistic proposal.
Authors:
Katherine Belecki; Craig A Townsend
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-08
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-31     Completed Date:  2013-06-18     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11316-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.
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MeSH Terms
Descriptor/Qualifier:
Enediynes / metabolism*
Escherichia coli / genetics,  metabolism
Polyketide Synthases / biosynthesis,  metabolism*
Polyketides / analysis,  metabolism*
Protein Structure, Tertiary
Grant Support
ID/Acronym/Agency:
ES001670/ES/NIEHS NIH HHS; R01 ES001670/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Enediynes; 0/Polyketides; 79956-01-7/Polyketide Synthases
Comments/Corrections

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