Document Detail


Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders.
MedLine Citation:
PMID:  17614759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a growing awareness of the central role played by environmental factors in many of the most debilitating neural disorders. Epidemiological studies have suggested a complex balance between genetic and environmental factors in the pathogenesis of neurological and psychiatric conditions. The use of accurate animal models, combined with experimental manipulations such as environmental enrichment, has shown that increased sensory, cognitive and motor stimulation has beneficial effects in a range of CNS disorders, including Huntington's, Alzheimer's, Parkinson's and other neurodegenerative diseases. Various studies have identified molecular, structural and functional correlates of this experience-dependent plasticity. The authors propose that the molecular systems which mediate the therapeutic effects of environmental enrichment may provide novel targets for pharmacotherapies. More specifically, they elaborate a theoretical framework for the development of 'enviromimetics', therapeutics that mimic or enhance the beneficial effects of environmental stimulation, targeted towards a wide range of nervous system disorders.
Authors:
Caitlin E McOmish; Anthony J Hannan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  11     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  899-913     Citation Subset:  IM    
Affiliation:
Howard Florey Institute, University of Melbourne, VIC 3010, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Diseases / drug therapy*,  etiology,  genetics,  physiopathology
Environment*
Humans
Neuronal Plasticity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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