Document Detail


Envelope coding in auditory nerve fibers following noise-induced hearing loss.
MedLine Citation:
PMID:  20556628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent perceptual studies suggest that listeners with sensorineural hearing loss (SNHL) have a reduced ability to use temporal fine-structure cues, whereas the effects of SNHL on temporal envelope cues are generally thought to be minimal. Several perceptual studies suggest that envelope coding may actually be enhanced following SNHL and that this effect may actually degrade listening in modulated maskers (e.g., competing talkers). The present study examined physiological effects of SNHL on envelope coding in auditory nerve (AN) fibers in relation to fine-structure coding. Responses were compared between anesthetized chinchillas with normal hearing and those with a mild-moderate noise-induced hearing loss. Temporal envelope coding of narrowband-modulated stimuli (sinusoidally amplitude-modulated tones and single-formant stimuli) was quantified with several neural metrics. The relative strength of envelope and fine-structure coding was compared using shuffled correlogram analyses. On average, the strength of envelope coding was enhanced in noise-exposed AN fibers. A high degree of enhanced envelope coding was observed in AN fibers with high thresholds and very steep rate-level functions, which were likely associated with severe outer and inner hair cell damage. Degradation in fine-structure coding was observed in that the transition between AN fibers coding primarily fine structure or envelope occurred at lower characteristic frequencies following SNHL. This relative fine-structure degradation occurred despite no degradation in the fundamental ability of AN fibers to encode fine structure and did not depend on reduced frequency selectivity. Overall, these data suggest the need to consider the relative effects of SNHL on envelope and fine-structure coding in evaluating perceptual deficits in temporal processing of complex stimuli.
Authors:
Sushrut Kale; Michael G Heinz
Related Documents :
22847828 - Ocular anatomy and retinal photoreceptors in a skink, the sleepy lizard (tiliqua rugosa).
23913948 - The spatiotemporal dynamics of rheotactic behavior depends on flow speed and available ...
7954078 - Evaluation of the relative roles of slowly and rapidly adapting afferent fibers in roug...
1324958 - A statistical study of cochlear nerve discharge patterns in response to complex speech ...
16750238 - Cone phototransduction and growth of the erg b-wave during light adaptation.
16656288 - Prediction of growth rate at different light levels from measured photosynthesis and re...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-06-16
Journal Detail:
Title:  Journal of the Association for Research in Otolaryngology : JARO     Volume:  11     ISSN:  1438-7573     ISO Abbreviation:  J. Assoc. Res. Otolaryngol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-03-03     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  100892857     Medline TA:  J Assoc Res Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Auditory Perception / physiology
Chinchilla
Cochlear Nerve / physiology*
Hearing Loss, Noise-Induced / physiopathology*
Hearing Loss, Sensorineural / physiopathology*
Male
Models, Animal
Grant Support
ID/Acronym/Agency:
R01 DC009838/DC/NIDCD NIH HHS; R01 DC009838-01A1/DC/NIDCD NIH HHS; R01DC009838/DC/NIDCD NIH HHS; R03 DC007348/DC/NIDCD NIH HHS; R03 DC007348-04/DC/NIDCD NIH HHS; R03DC007348/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Imaging evaluation of the patient with worst headache of life--it's not all subarachnoid hemorrhage.
Next Document:  A generic constitutive model for the passive porcine coronary artery.