Document Detail


Entry of low doses of mercury vapor into the nervous system.
MedLine Citation:
PMID:  9498219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inorganic mercury remains within neurons indefinitely and has been implicated in some human neurodegenerative diseases. We were interested in finding the lowest dose of mercury vapor that resulted in mercury deposition in neurons. Female BALB/c mice were exposed to 25 micrograms mercury/m3 for 2-20 hr or 500 micrograms mercury/m3 for 5-240 min. To see if female mouse neurons were more susceptible to mercury vapor than male neurons, male and female BALB/c mice were exposed to 50 micrograms mercury/m3 for 4-24 hr. Mice were perfused with formalin 1-30 weeks after exposure and paraffin sections of brain, spinal cord and kidney were stained for mercury with silver nitrate autometallography. On light microscopy, spinal motor neurons contained mercury granules after 12 hr exposure to 25 micrograms mercury/m3 or after 30 min exposure to 500 micrograms mercury/m3. Mercury remained in motor neurons 30 weeks after exposure. In female mice, mercury was seen in motor neurons at half the exposure times of male mice. In conclusion, low doses of mercury vapor, well within WHO guidelines for safe human occupational exposure, enter and remain within motor neurons of mice.
Authors:
R Pamphlett; P Coote
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology     Volume:  19     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-21     Completed Date:  1998-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Affiliation:
Department of Pathology (Neuropathology Division), University of Sydney, Australia.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Brain / drug effects,  pathology
Dose-Response Relationship, Drug
Female
Kidney Tubules / drug effects,  pathology
Male
Mercury / administration & dosage,  toxicity*
Mice
Mice, Inbred BALB C
Motor Neurons / drug effects,  pathology
Nervous System / drug effects*
Sex Factors
Spinal Cord / drug effects,  pathology
Chemical
Reg. No./Substance:
7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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