Document Detail

Entry of low doses of mercury vapor into the nervous system.
MedLine Citation:
PMID:  9498219     Owner:  NLM     Status:  MEDLINE    
Inorganic mercury remains within neurons indefinitely and has been implicated in some human neurodegenerative diseases. We were interested in finding the lowest dose of mercury vapor that resulted in mercury deposition in neurons. Female BALB/c mice were exposed to 25 micrograms mercury/m3 for 2-20 hr or 500 micrograms mercury/m3 for 5-240 min. To see if female mouse neurons were more susceptible to mercury vapor than male neurons, male and female BALB/c mice were exposed to 50 micrograms mercury/m3 for 4-24 hr. Mice were perfused with formalin 1-30 weeks after exposure and paraffin sections of brain, spinal cord and kidney were stained for mercury with silver nitrate autometallography. On light microscopy, spinal motor neurons contained mercury granules after 12 hr exposure to 25 micrograms mercury/m3 or after 30 min exposure to 500 micrograms mercury/m3. Mercury remained in motor neurons 30 weeks after exposure. In female mice, mercury was seen in motor neurons at half the exposure times of male mice. In conclusion, low doses of mercury vapor, well within WHO guidelines for safe human occupational exposure, enter and remain within motor neurons of mice.
R Pamphlett; P Coote
Related Documents :
15204019 - Long term proteasome inhibition does not preferentially afflict motor neurons in organo...
19726649 - The proteasome-associated deubiquitinating enzyme usp14 is essential for the maintenanc...
24322829 - Human fronto-parietal and parieto-hippocampal pathways represent behavioral priorities ...
14635989 - Perceptual binding of sensory events: the inclusive characteristics model.
3434209 - Motor neuron disease, parkinsonism and dementia. report of a case with diffuse lewy bod...
7715809 - New observation on ubiquitinated neurons in the cerebral cortex of multiple system atro...
12546819 - Pet-1 ets gene plays a critical role in 5-ht neuron development and is required for nor...
10336079 - Neuroprotective effects of brain-derived neurotrophic factor in seizures during develop...
2754479 - Efferent neurons and suspected interneurons in s-1 vibrissa cortex of the awake rabbit:...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology     Volume:  19     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-21     Completed Date:  1998-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Department of Pathology (Neuropathology Division), University of Sydney, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Brain / drug effects,  pathology
Dose-Response Relationship, Drug
Kidney Tubules / drug effects,  pathology
Mercury / administration & dosage,  toxicity*
Mice, Inbred BALB C
Motor Neurons / drug effects,  pathology
Nervous System / drug effects*
Sex Factors
Spinal Cord / drug effects,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbat...
Next Document:  Responses to N-methyl-D-aspartate and kainic acid in cerebellar granule cells of lead-exposed rat pu...