Document Detail


Entrapped, non-neoplastic adenohypophysiocytes in human pituitary adenomas.
MedLine Citation:
PMID:  2272145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunoprofile of 76 human pituitary adenomas was studied with particular reference to the occurrence of entrapped, non-neoplastic pituitary cells. This phenomenon was defined as unevenly distributed, usually peripherally located cells forming less than 1% of the total cell population. The stellate contour of such passively incorporated cells departed from the more rounded shape of most principal, neoplastic cells. Thirty-six of the adenomas studied comprised one or more types of entrapped elements. According to the hormone produced, prolactin-(PRL-)cells most commonly occurred as a minor "foreign" component (seen in 23 of the adenomas), whereas growth hormone-(GH-) and adrenocorticotropic hormone-(ACTH-)cells rarely were trapped (seen in 5 and 4 of the adenomas. Entrapped follicle stimulating hormone-(FSH-), luteinizing hormone-(LH-), and thyroid-stimulating hormone-(TSH-)cells assumed an intermediate position (seen in 14, 17 and 15 of the adenomas, respectively).
Authors:
S Holck; L Klinken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neuropathology     Volume:  9     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Affiliation:
Institute of Pathology, Frederiksborg County Hospital, Hillerød, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / pathology*
Cell Transformation, Neoplastic / pathology*
Humans
Neurons / pathology
Pituitary Gland, Anterior / pathology*
Pituitary Hormones, Anterior / secretion
Pituitary Neoplasms / pathology*
Chemical
Reg. No./Substance:
0/Pituitary Hormones, Anterior

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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