Document Detail


Entrainment range of nonidentical circadian oscillators by a light-dark cycle.
MedLine Citation:
PMID:  24032859     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The suprachiasmatic nucleus (SCN) is a principal circadian clock in mammals, which controls physiological and behavioral daily rhythms. The SCN has two main features: Maintaining a rhythmic cycle of approximately 24 h in the absence of a light-dark cycle (free-running period) and the ability to entrain to external light-dark cycles. Both free-running period and range of entrainment vary from one species to another. To understand this phenomenon, we investigated the diversity of a free-running period by the distribution of coupling strengths in our previous work [Phys. Rev. E 80, 030904(R) (2009)]. In this paper we numerically found that the dispersion of intrinsic periods among SCN neurons influence the entrainment range of the SCN, but has little influence on the free-running periods under constant darkness. This indicates that the dispersion of coupling strengths determines the diversity in free-running periods, while the dispersion of intrinsic periods determines the diversity in the entrainment range. A theoretical analysis based on two coupled neurons is presented to explain the results of numerical simulations.
Authors:
Changgui Gu; Jinshan Xu; Zonghua Liu; Jos H T Rohling
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Publication Detail:
Type:  Journal Article     Date:  2013-08-02
Journal Detail:
Title:  Physical review. E, Statistical, nonlinear, and soft matter physics     Volume:  88     ISSN:  1550-2376     ISO Abbreviation:  Phys Rev E Stat Nonlin Soft Matter Phys     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-09-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136452     Medline TA:  Phys Rev E Stat Nonlin Soft Matter Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  022702     Citation Subset:  IM    
Affiliation:
Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
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