| Enthesitis in spondyloarthropathy. | |
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MedLine Citation:
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PMID: 10411377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation at the insertions of ligaments, tendons, or joint capsules to bone, which is termed enthesitis, is a characteristic feature of spondyloarthropathy. Because of the relative inaccessibility of the enthesis, the inflammatory, microbiologic, and immunologic events at that site have been poorly defined. Recent magnetic resonance imaging studies have drawn attention to the ubiquitous nature of enthesitis in spondyloarthropathies, especially adjacent to synovial joints. This may have implications for the mechanisms of synovitis in spondyloarthropathies. Magnetic resonance imaging studies also suggest that enthesitis lesions may be extensive, which could explain the diffuse nature of bone changes seen in some patients with spondyloarthropathies. The importance of enthesitis as a skeletal phenomenon in spondyloarthropathies has gained further support from transgenic models in which either tumor necrosis factor-alpha or bone morphogenetic protein-6 overexpression result in entheseal-associated polyarthropathy. |
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Authors:
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D McGonagle; M A Khan; H Marzo-Ortega; P O'Connor; W Gibbon; P Emery |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in rheumatology Volume: 11 ISSN: 1040-8711 ISO Abbreviation: Curr Opin Rheumatol Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-24 Completed Date: 1999-08-24 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 244-50 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, University of Leeds, UK. D.G.McGonagle@leeds.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bursitis / etiology*, pathology, radiography Humans Magnetic Resonance Imaging Spondylitis, Ankylosing / complications*, pathology, radiography Synovial Membrane / pathology, radiography Tendinopathy / etiology*, pathology, radiography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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