| Enthalpically driven peptide stabilization by protective osmolytes. | |
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MedLine Citation:
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PMID: 20657920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native beta-hairpin state. In contrast to entropically driven steric "crowding", this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding. |
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Authors:
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Regina Politi; Daniel Harries |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-26 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 46 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 6449-51 Citation Subset: IM |
Affiliation:
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Institute of Chemistry and The Fritz Haber Research Center, The Hebrew University, Jerusalem 91904, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbohydrates
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chemistry Osmolar Concentration Peptides / chemistry* Polymers / chemistry Protein Folding Protein Structure, Secondary Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Peptides; 0/Polymers; 0/polyol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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