Document Detail

Enterovirus in sudden unexpected deaths in infants.
MedLine Citation:
PMID:  8822284     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Conventional approaches to virus detection failed to provide convincing evidence of a viral etiology in sudden unexplained deaths in infants (SUDI). Many viruses may not have been detected by the routinely used methods; among them enteroviruses (EV) have seldom been found in SUDI. METHODS: In this study EV were sought directly in stools, in pharyngeal and tracheal samples and in myocardial and lung tissues, by using a nested PCR; they were also sought indirectly by detecting IgM antibodies with a new capture immunoassay. Twenty-four SUDI cases were divided into two groups: Group I, certainly associated with; or Group II, not associated with clinical, biologic or histologic signs of viral infection. RESULTS: EV were found in stools but their prevalence was not significantly different between Group I and Group II (20 and 22.2%, respectively). On the contrary EV were detected in respiratory tract and/or lung samples in 53.8% of infants of Group I and in none of Group II. Anti-EV IgM antibodies were detected in 55.5% of infants of Group I and in none of Group II. CONCLUSIONS: These results indicate that EV infection may be specifically associated with the subgroup of SUDI with viral signs, raising the question of its role in this condition.
L Grangeot-Keros; M Broyer; E Briand; J P Gut; S Turkoglü; P Chretien; D Emilie; E Dussaix; Y Lazizi; M Dehan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  15     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-06     Completed Date:  1996-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Laboratories of Microbiology and Immunology, Hôpital A. Béclère, Clamart, France.
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MeSH Terms
Base Sequence
Child, Preschool
Enterovirus Infections / complications*,  diagnosis,  epidemiology
Infant, Newborn
Molecular Sequence Data
Polymerase Chain Reaction
Risk Factors
Sudden Infant Death / etiology*

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