Document Detail

Enterovirus-associated encephalitis in the California encephalitis project, 1998-2005.
MedLine Citation:
PMID:  18959496     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Encephalitis is a relatively rare presentation of enterovirus (EV) infections. Clinical and epidemiologic characteristics of EV encephalitis (EVE) have not been well characterized. METHODS: Patients with encephalitis enrolled in the California Encephalitis Project from 1998 to 2005 were tested for a range of pathogens, including EV, using a standardized diagnostic algorithm. EVE was categorized as "confirmed" (EV detected in cerebrospinal fluid [CSF] or brain tissue) or "possible" (EV found in respiratory or fecal specimens or serum EV immunoglobulin [Ig] M detected). We compared clinical and epidemiologic characteristics of EVE with those of other infectious encephalitis cases. RESULTS: EVE was diagnosed in 73 (4.6%) of 1571 patients (45 confirmed cases, 28 possible cases); 11.1% of cases had other infectious causes. Patients with confirmed EVE were younger, although 27% were adults, who presented with significantly less severe symptoms. Serotypes identified in EVE cases correlated with the predominant serotype for the given year reported to the National Enterovirus Surveillance System at the Centers for Disease Control and Prevention. Two of 4 fatal EVE cases were associated with EV71. CONCLUSION: EVs are an important cause of encephalitis cases requiring hospitalization, in both children and adults. Our data suggest that EVE severity varies by serotype, confirm the importance of CSF/brain tissue polymerase chain reaction, and demonstrate that serum IgM findings are of little value in diagnosing EVE.
Ashley L Fowlkes; Somayeh Honarmand; Carol Glaser; Shigeo Yagi; David Schnurr; M Steven Oberste; Larry Anderson; Mark A Pallansch; Nino Khetsuriani
Related Documents :
10102176 - A retrospective study of canine house soiling: diagnosis and treatment.
9507556 - Sensing lead insulation defect resulting in a damage of the icd pulse generator case.
12804196 - Severe haemophilia following use of donor eggs: implications for screening of prospecti...
6167956 - After-potential oversensing by a programmable pulse generator.
9152586 - Transient postictal psychosis associated with a course of ect.
17568896 - Abdominal wall protrusion following herpes zoster.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  198     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1685-91     Citation Subset:  AIM; IM    
Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
California / epidemiology
Child, Preschool
Encephalitis, Viral / epidemiology*,  virology*
Enterovirus / classification,  isolation & purification
Enterovirus Infections / epidemiology*,  virology*
Middle Aged
Time Factors
Grant Support
5U01 C10 00309-04//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent ...
Next Document:  Age- and serotype-specific pediatric invasive pneumococcal disease: insights from systematic surveil...