| Enterovirus-associated encephalitis in the California encephalitis project, 1998-2005. | |
| | |
MedLine Citation:
|
PMID: 18959496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Encephalitis is a relatively rare presentation of enterovirus (EV) infections. Clinical and epidemiologic characteristics of EV encephalitis (EVE) have not been well characterized. METHODS: Patients with encephalitis enrolled in the California Encephalitis Project from 1998 to 2005 were tested for a range of pathogens, including EV, using a standardized diagnostic algorithm. EVE was categorized as "confirmed" (EV detected in cerebrospinal fluid [CSF] or brain tissue) or "possible" (EV found in respiratory or fecal specimens or serum EV immunoglobulin [Ig] M detected). We compared clinical and epidemiologic characteristics of EVE with those of other infectious encephalitis cases. RESULTS: EVE was diagnosed in 73 (4.6%) of 1571 patients (45 confirmed cases, 28 possible cases); 11.1% of cases had other infectious causes. Patients with confirmed EVE were younger, although 27% were adults, who presented with significantly less severe symptoms. Serotypes identified in EVE cases correlated with the predominant serotype for the given year reported to the National Enterovirus Surveillance System at the Centers for Disease Control and Prevention. Two of 4 fatal EVE cases were associated with EV71. CONCLUSION: EVs are an important cause of encephalitis cases requiring hospitalization, in both children and adults. Our data suggest that EVE severity varies by serotype, confirm the importance of CSF/brain tissue polymerase chain reaction, and demonstrate that serum IgM findings are of little value in diagnosing EVE. |
| | |
Authors:
|
Ashley L Fowlkes; Somayeh Honarmand; Carol Glaser; Shigeo Yagi; David Schnurr; M Steven Oberste; Larry Anderson; Mark A Pallansch; Nino Khetsuriani |
Related Documents
:
|
620866 - Yersinia enterocolitica as a cause of erythema nodosum. 8191636 - Extraskeletal myxoid chondrosarcoma with intracisternal microtubules. 10102176 - A retrospective study of canine house soiling: diagnosis and treatment. 12804196 - Severe haemophilia following use of donor eggs: implications for screening of prospecti... 20522396 - Optimizing radiology peer review: a mathematical model for selecting future cases based... 12974156 - Inverted sinonasal papilloma--a report of 31 cases and review of the literature. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 198 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-12 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 1685-91 Citation Subset: AIM; IM |
Affiliation:
|
Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. ahl4@cdc.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult California / epidemiology Child Child, Preschool Encephalitis, Viral / epidemiology*, virology* Enterovirus / classification, isolation & purification Enterovirus Infections / epidemiology*, virology* Female Humans Male Middle Aged Seasons Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
5U01 C10 00309-04//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent ...
Next Document: Age- and serotype-specific pediatric invasive pneumococcal disease: insights from systematic surveil...