Document Detail

Enteropathogens in adult patients with diarrhea and healthy control subjects: a 1-year prospective study in a Swedish clinic for infectious diseases.
MedLine Citation:
PMID:  10816147     Owner:  NLM     Status:  MEDLINE    
A 1-year prospective study was conducted to identify enteropathogens in adults with diarrhea (n=851) and in healthy control subjects (n=203) by use of conventional laboratory methods. Virulence factor genes for diarrheagenic Escherichia coli were detected by polymerase chain reaction. Enteropathogens were identified in 56% of patients and 16% of control subjects. The isolation rate was 65% for patients with symptoms for <1 week and for travelers; >1 pathogen was found in 11% of patients. The most frequent enteropathogens were Campylobacter (13% of patients), Clostridium difficile (13%), enterotoxigenic Escherichia coli (8%), Salmonella (7%), Shigella (4%), Blastocystis hominis (4%), calicivirus (3%), rotavirus (3%), enteroaggregative E. coli (2%), Aeromonas (2%), Giardia intestinalis (2%), Cryptosporidium (2%), and astrovirus (2%). Less frequently isolated (< or =1% of patients) were verotoxigenic E. coli, enteropathogenic E. coli, enteroinvasive E. coli, Entamoeba histolytica/Entamoeba dispar, microsporidia, and adenovirus. Fifty percent of the patients were hospitalized, and 43% needed intravenous fluids. The median duration of diarrhea was 14 days. Clinical features were not helpful for predicting the etiology of diarrhea.
B Svenungsson; A Lagergren; E Ekwall; B Evengård; K O Hedlund; A Kärnell; S Löfdahl; L Svensson; A Weintraub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2000-05-18
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  30     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-8     Citation Subset:  IM    
Karolinska Institute, Huddinge University Hospital, Sweden.
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MeSH Terms
Aged, 80 and over
Bacteria / classification,  isolation & purification
Bacterial Infections / epidemiology,  microbiology
Case-Control Studies
Diarrhea / microbiology*,  parasitology*,  virology
Eukaryota / classification,  isolation & purification
Feces / microbiology*,  parasitology*,  virology
Middle Aged
Prospective Studies
Protozoan Infections / epidemiology,  parasitology
Sweden / epidemiology
Virus Diseases / epidemiology,  virology
Viruses / classification,  isolation & purification
Comment In:
Clin Infect Dis. 2002 Dec 1;35(11):1452-3   [PMID:  12439820 ]

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