Document Detail

Enterohepatic circulation of chloramphenicol and its glucuronide in the rat by microdialysis using a hepato-duodenal shunt.
MedLine Citation:
PMID:  10665988     Owner:  NLM     Status:  MEDLINE    
A system consisting of a hepato-duodenal shunt in which the bile of a drug-treated donor rat was diverted to the duodenum of an untreated recipient rat via a bile cannula was used to assess the role of hepatic metabolism and enterohepatic circulation in the pharmacokinetics of chloramphenicol. Blood concentrations of unbound chloramphenicol and its glucuronide were measured by on-line microdialysis coupled to a microbore liquid chromatographic system. Results indicated that chloramphenicol and its glucuronide were detected in the blood of both donor and recipient rats following an intravenous 100 mg/kg dose of chloramphenicol succinate to the donor rat. Our finding suggests that although enterohepatic circulation contributed only to a minor extent (approximately 1.8%) was involved in the disposition of unbound chloramphenicol in the rat on-line microdialysis techniques were applicable for such studies.
T H Tsai; A Y Shum; C F Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  66     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2000  
Date Detail:
Created Date:  2000-02-28     Completed Date:  2000-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan.
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MeSH Terms
Chloramphenicol / pharmacokinetics*
Duodenum / metabolism*
Enterohepatic Circulation*
Glucuronides / pharmacokinetics*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Glucuronides; 56-75-7/Chloramphenicol

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