| Enterocytes: active cells in tolerance to food and microbial antigens in the gut. | |
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MedLine Citation:
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PMID: 22288583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enterocytes used to be studied particularly in terms of digestion protagonists. However, as the immune functions of the intestinal tract were better understood, it became clear that enterocytes are not mere bystanders concerning the induction of immune tolerance to dietary peptides and gut microbiota. In fact, enterocytes are involved actively in shaping the intestinal immune environment, designed for maintaining a non-belligerent state. This tolerant milieu of the gut immune system is achieved by keeping a balance between suppression and stimulation of the inflammatory responses. Our review presents the current state of knowledge concerning the relationship between enterocytes and immune cells (dendritic cells, lymphocytes), with emphasis on the enterocytes' impact on the mechanisms leading to the induction of oral tolerance. |
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Authors:
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N Miron; V Cristea |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 167 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-01-31 Completed Date: 2012-03-22 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Department of Immunology, University of Medicine and Pharmacy, Iuliu Haţieganu Cluj-Napoca, Romania. nicolae.miron@umfcluj.ro |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation Antigens Cytokines / immunology Dendritic Cells / immunology Digestive System / immunology*, microbiology* Enterocytes / immunology*, microbiology Food Humans Immune Tolerance* Inflammation / immunology, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Cytokines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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