Document Detail

Enterochromaffin cell density in the gastric mucosa of patients with chronic renal failure.
MedLine Citation:
PMID:  8703442     Owner:  NLM     Status:  MEDLINE    
Thirty patients with chronic renal failure (CRF) and 30 age- and sex-matched controls were assessed for gastrointestinal diseases by gastroscopy, serum gastrin determination, and routine clinical and laboratory evaluation. Biopsy specimens from their gastric oxyntic mucosa were immunohistochemically stained with monoclonal antibodies against serotonin (5-hydroxytryptamine) and chromogranin A, the latter staining all gastric endocrine cells, the former disclosing serotonin-containing enterochromaffin (EC) cells only. The average EC cell density (cells/mm2) in the CRF patients was significantly lower than in the controls: 2.6 vs 12.9 (p = 0.0005). The EC cell counts also correlated negatively with serum gastrin values (p = 0.0031). The densities of the chromogranin-positive cells did not differ between CRF patients (74 cells/mm2) and controls (76 cells/mm2) (p = 0.7559). We conclude that, in addition to the previously known findings of hypoacidity, persistent hypergastrinaemia, and G and parietal cell hyperplasia, CRF also reduces the number of oxyntic EC cells. The negative correlation between EC cell density and serum gastrin levels reflects the complex interplay between different endocrinological activities in the gastrointestinal tract.
I Rantala; I Paronen; H Kainulainen; K Ala-Kaila
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-09-09     Completed Date:  1996-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Pathology Unit, Tampere University Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Count
Enterochromaffin Cells / pathology*
Gastric Mucosa / pathology*
Kidney Failure, Chronic / pathology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Number of activated T-helper cells and NK cells in peripheral blood is decreased in severe Crohn's d...
Next Document:  The interference of gingival cell cultures with growth of selected bacteria.