| Enteroaggregative Escherichia coli: an emerging enteric pathogen. | |
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MedLine Citation:
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PMID: 15046233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enteroaggregative Escherichia coli (EAEC) represents an emerging pathogen that causes enteric and food-borne infectious diseases. Subgroups in many populations throughout the world are susceptible to EAEC infection. EAEC pathogenesis involves adherence to the intestinal mucosa; increased production and deposition of a mucus biofilm; and mucosal toxicity due to inflammation and cytokine release. Due to the heterogeneity of EAEC strains and differing host immune responses, not all EAEC infections are symptomatic. Recent data suggest that individuals with a homozygous genotype -251 AA single nucleotide polymorphism (SNP), in the IL-8 promoter region, are more susceptible to EAEC diarrhea. The HEp-2 cell adherent assay allows identification of EAEC's characteristic aggregative or "stacked brick" adherence pattern. Antimicrobial treatment of individuals who develop EAEC diarrhea should be individually based. Ciprofloxacin and rifaximin, compared to placebo, have been shown to significantly shorten the course of diarrhea in patients who developed EAEC infection. The objective of this review is to increase awareness of this important emerging pathogen and to discuss the epidemiology, pathogenesis, and host-pathogen factors associated with EAEC infection. |
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Authors:
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David B Huang; Pablo C Okhuysen; Zhi-Dong Jiang; Herbert L DuPont |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 99 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-29 Completed Date: 2004-05-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacterial Adhesion / physiology Child Communicable Diseases, Emerging / epidemiology*, microbiology, physiopathology Diarrhea / epidemiology*, microbiology, physiopathology Enterobacteriaceae / isolation & purification, pathogenicity* Escherichia coli / isolation & purification, pathogenicity* Escherichia coli Infections / epidemiology*, microbiology, physiopathology Humans Intestinal Mucosa / microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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