Document Detail

Enteroaggregative Escherichia coli: an emerging enteric pathogen.
MedLine Citation:
PMID:  15046233     Owner:  NLM     Status:  MEDLINE    
Enteroaggregative Escherichia coli (EAEC) represents an emerging pathogen that causes enteric and food-borne infectious diseases. Subgroups in many populations throughout the world are susceptible to EAEC infection. EAEC pathogenesis involves adherence to the intestinal mucosa; increased production and deposition of a mucus biofilm; and mucosal toxicity due to inflammation and cytokine release. Due to the heterogeneity of EAEC strains and differing host immune responses, not all EAEC infections are symptomatic. Recent data suggest that individuals with a homozygous genotype -251 AA single nucleotide polymorphism (SNP), in the IL-8 promoter region, are more susceptible to EAEC diarrhea. The HEp-2 cell adherent assay allows identification of EAEC's characteristic aggregative or "stacked brick" adherence pattern. Antimicrobial treatment of individuals who develop EAEC diarrhea should be individually based. Ciprofloxacin and rifaximin, compared to placebo, have been shown to significantly shorten the course of diarrhea in patients who developed EAEC infection. The objective of this review is to increase awareness of this important emerging pathogen and to discuss the epidemiology, pathogenesis, and host-pathogen factors associated with EAEC infection.
David B Huang; Pablo C Okhuysen; Zhi-Dong Jiang; Herbert L DuPont
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  99     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-05-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
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MeSH Terms
Bacterial Adhesion / physiology
Communicable Diseases, Emerging / epidemiology*,  microbiology,  physiopathology
Diarrhea / epidemiology*,  microbiology,  physiopathology
Enterobacteriaceae / isolation & purification,  pathogenicity*
Escherichia coli / isolation & purification,  pathogenicity*
Escherichia coli Infections / epidemiology*,  microbiology,  physiopathology
Intestinal Mucosa / microbiology

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