| Enteritis as a complication of adjuvant combination chemotherapy using 5-fluorouracil and leukovorin: clinical and helical computed tomographic features. | |
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MedLine Citation:
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PMID: 15233387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The combination of 5-flourouracil (5-FU) and leukovorin is widely used as adjuvant chemotherapy for metastatic colorectal carcinoma. The most common clinical side effects of 5-FU are related to its gastrointestinal toxicity, chiefly stomatitis and diarrhea. The latter may be severe in up to 30% and occasionally is life-threatening. We describe a case of therapy-induced enteritis presenting as acute abdominal pain and present the computed tomographic (CT) findings. In light of the prevalence of this regimen, the potential morbidity of this complication, and a paucity of CT examples in the radiologic literature, this case illustrates an important adverse effect of this medication. Early recognition and treatment should avoid significant morbidity and mortality. |
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Authors:
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Ramin Zamani; Maureen Heldmann |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society Volume: 156 ISSN: 0024-6921 ISO Abbreviation: J La State Med Soc Publication Date: 2004 May-Jun |
Date Detail:
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Created Date: 2004-07-05 Completed Date: 2004-07-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505618 Medline TA: J La State Med Soc Country: United States |
Other Details:
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Languages: eng Pagination: 143-4 Citation Subset: IM |
Affiliation:
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Department of Radiology, Louisiana State University Health Sciences Center, Shreveport, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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etiology Antimetabolites, Antineoplastic / adverse effects, therapeutic use Chemotherapy, Adjuvant Colonic Neoplasms / drug therapy Enteritis / chemically induced*, radiography Female Fluorouracil / adverse effects*, therapeutic use Humans Leucovorin / therapeutic use Middle Aged Tomography, Spiral Computed |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil; 58-05-9/Leucovorin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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