Document Detail

Enteritis as a complication of adjuvant combination chemotherapy using 5-fluorouracil and leukovorin: clinical and helical computed tomographic features.
MedLine Citation:
PMID:  15233387     Owner:  NLM     Status:  MEDLINE    
The combination of 5-flourouracil (5-FU) and leukovorin is widely used as adjuvant chemotherapy for metastatic colorectal carcinoma. The most common clinical side effects of 5-FU are related to its gastrointestinal toxicity, chiefly stomatitis and diarrhea. The latter may be severe in up to 30% and occasionally is life-threatening. We describe a case of therapy-induced enteritis presenting as acute abdominal pain and present the computed tomographic (CT) findings. In light of the prevalence of this regimen, the potential morbidity of this complication, and a paucity of CT examples in the radiologic literature, this case illustrates an important adverse effect of this medication. Early recognition and treatment should avoid significant morbidity and mortality.
Ramin Zamani; Maureen Heldmann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society     Volume:  156     ISSN:  0024-6921     ISO Abbreviation:  J La State Med Soc     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-07-05     Completed Date:  2004-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505618     Medline TA:  J La State Med Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-4     Citation Subset:  IM    
Department of Radiology, Louisiana State University Health Sciences Center, Shreveport, USA.
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MeSH Terms
Abdominal Pain / etiology
Antimetabolites, Antineoplastic / adverse effects,  therapeutic use
Chemotherapy, Adjuvant
Colonic Neoplasms / drug therapy
Enteritis / chemically induced*,  radiography
Fluorouracil / adverse effects*,  therapeutic use
Leucovorin / therapeutic use
Middle Aged
Tomography, Spiral Computed
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil; 58-05-9/Leucovorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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