| Enteric-coated Mycophenolate Sodium as a Corticosteroid-sparing Agent for the Treatment of Autoimmune Scleritis. | |
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MedLine Citation:
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PMID: 21099416 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : To evaluate enteric-coated mycophenolate sodium (EC-MPS) as a corticosteroid-sparing agent in the treatment of autoimmune scleritis. METHODS: : A retrospective, interventional, noncomparative review of EC-MPS use in patients with autoimmune scleritis. RESULTS: : Seven eyes of 5 patients (all female; median age: 47 years, range: 20-55 years) with inflammatory scleral disease were treated with EC-MPS. The mean follow-up duration was 16.4 months (range, 12-20 months). EC-MPS was started at 360 mg twice daily. The mean time to treatment success was 1.6 months (range, 1-3 months). The mean prednisolone dosage at the onset of EC-MPS was 24 mg daily (range, 15-30 mg), and this was reduced to 6.5 mg daily (range, 0-10 mg) as inflammation control was achieved. No severe adverse events except for 1 patient with transient knee pain were reported; the incidence of adverse events after using EC-MPS was 1/6.83 person-years. There was no recurrence of scleral inflammation during the follow-up period. CONCLUSIONS: : EC-MPS can be used as a corticosteroid-sparing agent to safely suppress inflammatory autoimmune scleritis. |
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Authors:
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Yih-Shiou Hwang; Hung-Chi Jesse Chen; Kuan-Jen Chen; Chi-Chun Lai; Ling Yeung; Ko-Jen Yang; Ken-Kuo Lin; Ching-Hsi Hsiao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cornea Volume: 30 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 260-4 Citation Subset: IM |
Affiliation:
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From the *Department of Ophthalmology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan, ROC; †Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, China and ‡Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC; and §Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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