| Enteric bacteriology, absorption, morphology and emptying after ileal pouch-anal anastomosis. | |
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MedLine Citation:
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PMID: 3790923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim was to determine whether changes in enteric bacteriology, absorption, morphology, and emptying occur after ileal pouch-anal anastomosis for ulcerative colitis, and to relate any changes to the clinical result. Twenty patients were studied 26 +/- 2 months (mean +/- s.e.m.) after operation. Eight patients had a good result, six a poor result, and six a history of recurrent pouch ileitis. Anaerobic and aerobic overgrowth occurred in the jejunum of patients with a poor result, but not in those with a good result or with pouch ileitis. In contrast, ileal pouch bacterial overgrowth occurred in all patients regardless of the clinical result. Patients with jejunal overgrowth had increased 24 h stool volume and stool nitrogen, but other patients did not. The larger the stool volume, the greater the anaerobic overgrowth. Pouch biopsies showed chronic inflammation in all patients, while 45 per cent had colonic metaplasia. Neither the inflammation nor the metaplasia correlated with the clinical result, nor did the clinical result correlate with the efficiency of pouch emptying. In conclusion, jejunal bacterial overgrowth after ileal pouch-anal anastomosis was associated with an increased stool output, azotorrhoea, and a poor clinical result. A distinguishing bacterial, absorptive, morphological, or emptying abnormality was not found in patients with a history of recurrent pouch ileitis. |
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Authors:
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P R O'Connell; D R Rankin; L H Weiland; K A Kelly |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The British journal of surgery Volume: 73 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-02-05 Completed Date: 1987-02-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 909-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anal Canal
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surgery* Colitis, Ulcerative / complications, microbiology, physiopathology, surgery* Female Gastrointestinal Motility Humans Ileitis / complications Ileum / microbiology, physiopathology, surgery* Intestinal Absorption Male |
| Grant Support | |
ID/Acronym/Agency:
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AM18278/AM/NIADDK NIH HHS; AM34988/AM/NIADDK NIH HHS; TW03501/TW/FIC NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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