Document Detail

Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis.
MedLine Citation:
PMID:  8424426     Owner:  NLM     Status:  MEDLINE    
To ascertain the role of total enteral nutrition, compared with total parenteral nutrition, as adjunct therapy to steroids in patients with severe acute ulcerative colitis, a prospective randomized trial was conducted in 42 of such patients. Inclusion criteria were the persistence of a moderate or severe attack of the disease (Truelove's index) after 48 h on full steroid treatment (prednisone 1 mg/kg/day). Patients were randomized to receive polymeric total enteral nutrition or isocaloric, isonitrogenous total parenteral nutrition as the sole nutritional support. Remission rate and need for colectomy were similar in both groups. No significant changes in anthropometric parameters were observed in either nutritional group at the end of the study. Median increase in serum albumin was 16.7% (-0.5% to +30.4%) in the enteral feeding group, and only 4.6% (-12.0% to +13.7%) in the parenteral nutrition patients (p = 0.019). Adverse effects related to artificial nutritional support were less frequent (9% vs. 35%, p = 0.046) and milder in enterally fed patients. Postoperative infections occurred more often with parenteral nutrition (p = 0.028). These results suggest that total enteral nutrition is safe and nutritionally effective in severe attacks of ulcerative colitis. It is also cheaper and associated with fewer complications than parenteral nutrition. Total enteral nutrition should be regarded as the most suitable type of nutritional support in these patients.
F González-Huix; F Fernández-Bañares; M Esteve-Comas; A Abad-Lacruz; E Cabré; D Acero; M Figa; M Guilera; P Humbert; R de León
Related Documents :
19207806 - Does nutritional intervention for patients with hip fractures reduce postoperative comp...
17054196 - Early enteral nutrition within 24h of colorectal surgery versus later commencement of f...
3970606 - Is routine postoperative nasogastric decompression really necessary?
16843906 - Study of hypocaloric peripheral parenteral nutrition in postoperative patients (europea...
21119966 - Have tsetse flies disappeared from brazzaville town?
23114016 - Evaluation of helicobacter pylori eradication in pediatric patients by triple therapy p...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  88     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Digestive Diseases Unit, Hospital Josep Trueta, Girona, Catalunya, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Colitis, Ulcerative / blood,  therapy*
Combined Modality Therapy
Enteral Nutrition* / adverse effects,  economics
Middle Aged
Nutritional Status
Parenteral Nutrition, Total* / adverse effects,  economics
Postoperative Complications
Prednisone / therapeutic use
Prospective Studies
Serum Albumin / analysis
Reg. No./Substance:
0/Serum Albumin; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A 4-week, multicenter, duodenal ulcer healing trial comparing four escalating doses of ranitidine.
Next Document:  Lymphoblastoid alpha-interferon for chronic hepatitis C: a randomized controlled study.