| Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis. | |
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MedLine Citation:
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PMID: 8424426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To ascertain the role of total enteral nutrition, compared with total parenteral nutrition, as adjunct therapy to steroids in patients with severe acute ulcerative colitis, a prospective randomized trial was conducted in 42 of such patients. Inclusion criteria were the persistence of a moderate or severe attack of the disease (Truelove's index) after 48 h on full steroid treatment (prednisone 1 mg/kg/day). Patients were randomized to receive polymeric total enteral nutrition or isocaloric, isonitrogenous total parenteral nutrition as the sole nutritional support. Remission rate and need for colectomy were similar in both groups. No significant changes in anthropometric parameters were observed in either nutritional group at the end of the study. Median increase in serum albumin was 16.7% (-0.5% to +30.4%) in the enteral feeding group, and only 4.6% (-12.0% to +13.7%) in the parenteral nutrition patients (p = 0.019). Adverse effects related to artificial nutritional support were less frequent (9% vs. 35%, p = 0.046) and milder in enterally fed patients. Postoperative infections occurred more often with parenteral nutrition (p = 0.028). These results suggest that total enteral nutrition is safe and nutritionally effective in severe attacks of ulcerative colitis. It is also cheaper and associated with fewer complications than parenteral nutrition. Total enteral nutrition should be regarded as the most suitable type of nutritional support in these patients. |
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Authors:
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F González-Huix; F Fernández-Bañares; M Esteve-Comas; A Abad-Lacruz; E Cabré; D Acero; M Figa; M Guilera; P Humbert; R de León |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 88 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-02-25 Completed Date: 1993-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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Digestive Diseases Unit, Hospital Josep Trueta, Girona, Catalunya, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Colectomy Colitis, Ulcerative / blood, therapy* Combined Modality Therapy Enteral Nutrition* / adverse effects, economics Female Hospitalization Humans Male Middle Aged Nutritional Status Parenteral Nutrition, Total* / adverse effects, economics Postoperative Complications Prednisone / therapeutic use Prospective Studies Serum Albumin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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