| Enteral ornithine alpha-ketoglutarate enhances intestinal adaptation to massive resection in rats. | |
| | |
MedLine Citation:
|
PMID: 9826214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ornithine alpha-ketoglutarate (OKG) has been advocated in the treatment of critically ill patients for its anabolic effect on protein metabolism. Since OKG is a precursor of glutamine, arginine, and polyamines, key substrates of intestinal metabolism and function, we investigated the influence of OKG on intestinal adaptation and trophicity and on glutamine status after small bowel resection. After massive (80%) small bowel resection, rats were enterally fed for 7 days with a standard diet supplemented with either OKG (2 g/kg/d) or an isonitrogenous amount of glycine. OKG induced an adaptative hyperplasia of the villi, demonstrated in the jejunum by an increase in the villus height to crypt depth ratio (OKG v control, 4.3+/-0.4 v 3.3+/-0.5, P < .01) along with an increase (P < .05) in ornithine decarboxylase (ODC) activity (+80%) and ornithine content (+102%). Plasma glutamine (+25%) and muscle glutamine (anterior tibialis [AT], +43%; extensor digitorum longus [EDL], +54%) and protein (AT, +32%) were significantly higher (P < .05) after OKG administration, supporting its role in the restoration of glutamine pools. In summary, enterally administered OKG, which enhances intestinal adaptation after massive resection and improves muscle glutamine and protein content, could contribute significantly to nutritional management after small bowel resection. |
| | |
Authors:
|
F Dumas; J P De Bandt; V Colomb; J Le Boucher; C Coudray-Lucas; S Lavie; N Brousse; C Ricour; L Cynober; O Goulet |
Related Documents
:
|
17638014 - Morphological changes of the rat intestinal lining in relation to body stores depletion... 11877654 - Intestinal permeability and bacterial translocation are uncoupled after small bowel res... 6780704 - Maintenance of gi function after bowel surgery and immediate enteral full nutrition. i.... 20424834 - Changes in the intestinal microbiota of wild atlantic cod gadus morhua l. upon captive ... 8104734 - Differential responses of two inbred rat strains to a choline-deficient diet during liv... 11684524 - Long-term weight-loss maintenance: a meta-analysis of us studies. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 47 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1998-12-02 Completed Date: 1998-12-02 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1366-71 Citation Subset: IM |
Affiliation:
|
Laboratoire de Biochimie A, Hôpital Necker AP-HP, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects* Amino Acids / blood, metabolism Animals Enteral Nutrition Intestinal Mucosa / drug effects Intestine, Small / drug effects*, physiology, surgery Male Muscles / metabolism Ornithine / administration & dosage, analogs & derivatives*, pharmacology Proteins / metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Proteins; 37339-58-5/ornithine alpha-ketoglutarate; 7006-33-9/Ornithine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leptin does not affect adipocyte glucose metabolism: studies in fresh and cultured adipocytes.
Next Document: Insulin sensitivity, insulin action, and fibrinolysis activity in nondiabetic and diabetic obese sub...