Document Detail


Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study.
MedLine Citation:
PMID:  16769348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: The presence of granulocyte colony-stimulating factor (G-CSF) in human milk and the expression of G-CSF receptors on intestinal villous enterocytes of neonates suggest that G-CSF has a role in the development and integrity of the gastrointestinal tract. We hypothesized that enteral recombinant human G-CSF (rhG-CSF) given to preterm infants with necrotizing enterocolitis (NEC) in the earlier stages could protect against disease progression and complications. METHODS: Preterm infants with mild (stage I) NEC (n = 18) were assigned to receive enteral rhG-CSF (n = 8) or placebo (n = 10) for 5 days from the first day of the diagnosis. Clinical and gastrointestinal parameters were followed during the whole period of hospitalization. RESULTS: In the study group, none of the infants with stage I NEC had a clinical progression to stage II or III, whereas in the control group, 5 (50%) infants with stage I NEC had a disease progression to stage II or III (P < .05). In the study group, the time required for the resolution of clinical and radiological findings of NEC and the total duration of systemic therapy and hospitalization were significantly shorter than the control group (P < .001). CONCLUSION: Enteral rhG-CSF treatment could prevent the progression of mild (stage I) NEC to further stages and decrease the time required for the resolution of clinical and radiological signs of the disease.
Authors:
Fuat Emre Canpolat; Murat Yurdakök; Ayşe Korkmaz; Sule Yiğit; Gülsevin Tekinalp
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  41     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1134-8     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Department of Pediatrics, Neonatology, Hacettepe University, Ankara, Turkey. femrecan@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Disease Progression
Enterocolitis, Necrotizing / drug therapy*,  physiopathology,  radiography
Female
Granulocyte Colony Stimulating Factor, Recombinant / administration & dosage*,  therapeutic use
Humans
Infant, Newborn
Intubation, Gastrointestinal
Male
Pilot Projects
Treatment Outcome
Chemical
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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