| Enteral glutamine supplementation impairs intestinal blood flow in rats. | |
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MedLine Citation:
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PMID: 18466863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinical studies have shown that enteral immune-enhancing diets (IEDs) containing l-glutamine decrease septic complications and length of stay in some patient populations. Animal studies suggest IED benefits might include augmented gut blood flow. We hypothesized that enteral glutamine supplementation modulates gastrointestinal blood flow. METHODS: Blood flow was measured in male Sprague-Dawley rats via the colorimetric microsphere technique at baseline, 60, and 120 minutes. Four groups were studied: (1) control diet (CD) + enteral glutamine; (2) CD + enteral glycine; (3) CD + enteral saline; and (4) CD + intravenous glutamine. RESULTS: There were no differences in blood pressure or heart rate in any group. Group 1 blood flow was decreased at 120 minutes compared with controls (groups 2 and 3) in small intestine, colon, spleen, and pancreas, whereas the intravenous glutamine group (group 4) had no effect on blood flow. CONCLUSIONS: Enteral glutamine supplementation (as in IEDs) appears to impair gastrointestinal blood flow. Because glutamine provides energy directly to active enterocytes, enteral glutamine availability might diminish metabolic stimuli of absorptive hyperemia. This finding might partially explain the benefits observed with parenteral versus enteral glutamine supplementation in clinical studies (such as bone-marrow-transplant patients). |
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Authors:
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Paul J Matheson; Brady T Harris; Ryan T Hurt; E Rasheid Zakaria; R Neal Garrison |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-05-07 |
Journal Detail:
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Title: American journal of surgery Volume: 196 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-08-07 Revised Date: 2009-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 293-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Louisville, 800 Zorn Ave., Research Building 19, Louisville, KY 40206, USA. paul.matheson@louisville.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colorimetry Enteral Nutrition* Glutamine / administration & dosage, adverse effects* Intestines / blood supply* Male Pancreas / blood supply Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects* Spleen / blood supply |
| Chemical | |
Reg. No./Substance:
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56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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