Document Detail

Enteral feeding in sepsis: a prospective, randomized, double-blind trial.
MedLine Citation:
PMID:  3931273     Owner:  NLM     Status:  MEDLINE    
In an attempt to meet better the needs of patients with hypermetabolic stress, amino acid formulas have been modified (MAA). As part of a total parenteral nutrition regimen, MAA have been associated with improvement in parameters of nutrition and survival. The safety and efficacy of these formulas in balanced enteral nutrition was assessed in malnourished patients with moderate to high levels of stress undergoing surgery. The nutritional targets were 5 gm/kg/day glucose, 0.8 gm/kg/day fat, and 0.27 gm/kg/day amino acid nitrogen. In an initial nine studies, the MAA nutrition was safe even in the presence of ileus. A double-blind, randomized, prospective trial was then undertaken in 18 patients in an isocaloric, isonitrogenous design with the nitrogen source as MAA (44% branched-chain amino acids) or standard amino acids (28% branched-chain amino acids). The patients receiving MAA had enhanced nitrogen retention, visceral protein mass, and indices of survival.
F B Cerra; E P Shronts; N N Konstantinides; S Thoele; F N Konstantinides; K Teasley; J Lysne
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery     Volume:  98     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-01     Completed Date:  1985-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  632-9     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids, Branched-Chain / administration & dosage*,  analysis
Clinical Trials as Topic
Double-Blind Method
Enteral Nutrition*
Lactates / blood
Lactic Acid
Middle Aged
Nitrogen / urine
Nutrition Disorders / therapy
Nutritional Requirements
Prospective Studies
Random Allocation
Sepsis / blood,  therapy*
Serum Albumin / analysis
Transferrin / analysis
Triglycerides / blood
Urea / urine
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Lactates; 0/Serum Albumin; 0/Triglycerides; 11096-37-0/Transferrin; 50-21-5/Lactic Acid; 57-13-6/Urea; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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