| Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients. | |
| | |
MedLine Citation:
|
PMID: 17052809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: Circulating carotenoid levels decrease progressively in patients receiving long-term enteral tube feeding with carotenoid-free formulas. Low dietary intake and low blood levels of carotenoids are associated with a higher risk of morbidity and mortality from chronic diseases. The aim of this study was to examine the effects of a low dose carotenoid mixture (3-mg/1500kcal) for 3 months on serum carotenoid levels and oxidative stress in patients receiving long-term enteral nutrition as the sole source of nutrition. METHODS: This randomized, double blind, controlled study compared patients receiving enteral nutrition with carotenoids (N=26) and without carotenoids (control group; N=25). RESULTS: Patients on long-term enteral nutrition had low baseline serum carotenoid levels. Three months of enteral feeding enriched with carotenoids significantly (P<0.01) increased serum carotenoid levels compared with the control group. Oxidative stress as measured by NF-kappaB levels was decreased at 3 months compared with the control group (P<0.05). No significant changes in MDA levels were observed during the study period in either group. CONCLUSIONS: This study demonstrated that enteral nutrition containing small amounts of carotenoids (3-mg/1500kcal) in patients requiring long-term enteral feeding normalizes serum carotenoid levels to the lower end of the range found in age-matched controls. The NF-kappaB data indicate a reduction in oxidative stress in these patients. Therefore, the use of formulas containing a mixture of carotenoids should be recommended for long-term enteral nutrition. |
| | |
Authors:
|
Nachum Vaisman; Guido R M M Haenen; Yahalomit Zaruk; Carin Verduyn; Jacques G Bindels; Sjors Verlaan; Erwin P Meijer |
Related Documents
:
|
2291429 - Anorexia/bulimia nervosa: the development of anorexia nervosa and of mental symptoms. t... 16511929 - Effect of inflammatory activity and glucocorticoid [corrected] use on nutritional varia... 11100349 - Early use of cyclic tpn prevents further deterioration of liver functions for the tpn p... 22323189 - Expression of dominant-negative ikaros isoforms and associated genetic alterations in c... 1251759 - Lithium treatment and weight gain. 22572859 - Activated innate immunity and the involvement of cx3cr1-fractalkine in promoting hematu... 23025269 - New biomarker for neovascular age-related macular degeneration: eotaxin-2. 7930469 - Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic p... 22990619 - Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing m... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2006-10-18 |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: 25 ISSN: 0261-5614 ISO Abbreviation: Clin Nutr Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-11-22 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 897-905 Citation Subset: IM |
Affiliation:
|
Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, Tel-Aviv, 64239, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antioxidants / administration & dosage*, metabolism Carotenoids / administration & dosage*, blood* Double-Blind Method Enteral Nutrition* Female Humans Male Malondialdehyde / blood NF-kappa B Nutritional Status* Oxidative Stress* / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/NF-kappa B; 36-88-4/Carotenoids; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition.
Next Document: What maintains parental support for vaccination when challenged by anti-vaccination messages? A qual...