| Enteral feeding of a chemically defined diet preserves pulmonary immunity but not intestinal immunity: the role of lymphotoxin beta receptor. | |
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MedLine Citation:
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PMID: 17947602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Compared with chow or a complex enteral diet (CED), IV administration of a parenteral nutrition solution (IV-PN) impairs intestinal and respiratory mucosal immunity, resulting in cellular and immunoglobulin A (IgA) defects in the intestine and impaired respiratory antiviral and antibacterial defenses. PN given intragastrically (IG-PN) impairs intestinal immunity similar to IV-PN but preserves antiviral defences and partially preserves antibacterial defenses. Lymphotoxin beta receptor (LTbetaR) is a molecule essential for development and organization of lymphoid tissue. It controls many molecules important in mucosal immune integrity. This study examines effects of route (IV or enteral) and type (PN, CED, or chow) on murine intestine and lung LTbetaR expression. METHODS: Forty-three mice randomly received IV-PN (n = 12), IG-PN (n = 11), IV saline + chow (chow; n = 11), or a CED (n = 9). After 5 days of feeding, intestinal and lung samples were obtained and processed for levels of LTbetaR by Western blot. RESULTS: IV-PN significantly reduced intestinal and lung LTbetaR compared with CED and chow. IG-PN reduced LTbetaR levels only in the intestine but preserved lung levels. CONCLUSIONS: Route and type of nutrition differentially influence molecular events in the intestinal and respiratory mucosal immune systems. Enteral feeding with any diet (complex or chemically defined) maintains lung LTbetaR expression, whereas intestinal LTbetaR levels are maintained only with CEDs (chow and CED). We hypothesize that LTbetaR is responsible for the observed preservation of respiratory tract immunity with administration of a noncomplex, chemically defined enteral diet, whereas intestinal immunity is compromised with this diet. |
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Authors:
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Kenneth A Kudsk; F Enrique Gomez; Woodae Kang; Chikara Ueno |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 31 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-10-19 Completed Date: 2008-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 477-81 Citation Subset: IM |
Affiliation:
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Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA. kudsk@surgery.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Drug Administration Routes Enteral Nutrition* Gene Expression Regulation Immunity, Mucosal / drug effects*, physiology Immunoglobulin A / biosynthesis Immunoglobulins / biosynthesis Infusions, Intravenous Intestinal Mucosa / metabolism* Intestine, Small / immunology Lung / cytology, immunology*, metabolism Lymphotoxin beta Receptor / genetics, metabolism, physiology* Male Mice Mice, Inbred ICR Parenteral Nutrition* Peyer's Patches / cytology, immunology, metabolism Random Allocation |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM53439/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulins; 0/Lymphotoxin beta Receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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