Document Detail

Enteral Zinc Supplementation and Growth in Extremely Low Birth Weight Infants with Chronic Lung Disease.
MedLine Citation:
PMID:  24121149     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: Zinc deficiency causes growth deficits. Extremely low birth weight (ELBW) infants with chronic lung disease (CLD), also known as bronchopulmonary dysplasia (BPD), suffer from growth failure and are at risk of zinc deficiency. We hypothesized that enteral zinc supplementation would increase weight gain and linear growth.
METHODS:: A cohort of infants was examined retrospectively at a single center between January 2008 and December 2011. CLD was defined as the need for oxygen at 36 weeks postmenstrual age. Zinc supplementation was started in infants who had poor weight gain. Infants' weight gain and linear growth were compared before and after zinc supplementation using paired t-test.
RESULTS:: 52 ELBW infants with CLD met entry criteria. Mean birth weight was 682 grams ±183 and gestational age 25.3 weeks ±2. Zinc supplementation started at post-menstrual age 33 weeks ±2. Most infants received fortified human milk. Weight gain increased from 10.9 before supplementation to 19.9 g/kg/day after supplementation (p < 0.0001). Linear growth increased from 0.7 to 1.1 cm/week (p = 0.001).
CONCLUSIONS:: Zinc supplementation improved growth in ELBW infants with CLD on human milk. Further investigation is warranted to re-evaluate zinc requirements, markers, and balance.
Ala K Shaikhkhalil; Jennifer Curtiss; Teresa D Puthoff; Christina J Valentine
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-9
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Nationwide Children's Hospital, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 700 Children's Drive Columbus, OH 43205 †Nationwide Children's Hospital, Section of Neonatology, 700 Children's Drive, Columbus Ohio 43205 ‡Nationwide Children's Hospital, Department of Pharmacy Services, 700 Children's Drive, Columbus Ohio 43205 §Cincinnati Children's Hospital Medical Center, Division of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229.
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