| Entecavir for chronic hepatitis B: a review. | |
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MedLine Citation:
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PMID: 18223455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three nucleotide/nucleoside analogs are currently used for the treatment of chronic hepatitis B: lamivudine, adefovir dipivoxil, and entecavir. Lamivudine and adefovir are beneficial for oral administration and safety, but only a few of the patients treated experience a sustained response after therapy withdrawal. Entecavir, a cyclopentyl guanosine analog, is a potent inhibitor of chronic hepatitis B virus DNA polymerase, inhibiting both the priming and elongation steps of viral DNA replication. In phase II and phase III clinical trials, entecavir was found to be superior to lamivudine for all primary end points evaluated in both nucleoside-naive and lamivudine-resistant patients as well as being effective in both HBeAg-positive and HBeAg-negative nucleoside-naive patients. Only one trial has shown evidence of cases of viral resistance to this drug. The approved dosage in treatment-naive patients is 0.5 mg per day orally, whereas in patients who have failed lamivudine therapy or are known to harbor lamivudine-resistant mutants, the approved dosage is 1.0 mg per day. |
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Authors:
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Emilio Palumbo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 30 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Affiliation:
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Clinic of Paediatrics, Hospital of Sondrio, Foggia, Italy. emipalu2003@yahoo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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adverse effects,
pharmacology,
therapeutic use* Guanine / adverse effects, analogs & derivatives*, pharmacology, therapeutic use Hepatitis B, Chronic / drug therapy* Humans Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/entecavir; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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