Document Detail

Entamoeba histolytica extract and interferon-gamma activation of macrophage-mediated amoebicidal function.
MedLine Citation:
PMID:  1398736     Owner:  NLM     Status:  MEDLINE    
The effect of recombinant murine interferon-gamma (IFN-gamma) and E. histolytica extract (E.h.E.) on macrophage (M phi) activation for amoebicidal activity was examined. Peritoneal macrophages were harvested from C57BL/6 and A/J mice and preincubated with IFN-gamma and/or E.h.E. It was found that amoebicidal activity could be induced in both C57BL/6 and A/J-derived macrophages by pretreatment with IFN-gamma and E.h.E. Pretreatment of the M phi with E. histolytica extract or IFN-gamma alone did not result in the activation of significant cytotoxic activity against E. histolytica trophozoites. In the presence of IFN-gamma, E.h.E. had a dose-dependent effect on the activation of M phi amoebicidal function.
E Ghadirian; M Denis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunobiology     Volume:  185     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-11-05     Completed Date:  1992-11-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Montreal General Hospital Research Institute, Quebec, Canada.
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MeSH Terms
Adjuvants, Immunologic / pharmacology
Cytotoxicity, Immunologic / drug effects
Dose-Response Relationship, Immunologic
Drug Synergism
Entamoeba histolytica / chemistry,  immunology*
Immunity, Cellular / drug effects
Interferon-gamma / pharmacology*
Macrophage Activation / drug effects*
Macrophages / immunology
Mice, Inbred A
Mice, Inbred C57BL
Tumor Necrosis Factor-alpha / immunology
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Tumor Necrosis Factor-alpha; 82115-62-6/Interferon-gamma

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