| Enoximone versus dopamine in patients being weaned from cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 2148278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of acute haemodynamic support with intravenous enoximone (2 X bolus 0.5 mg/kg; infusion 5.0 micrograms/kg/min) versus dopamine (3.0-4.0 micrograms/kg/min), over an 18-hour period, was investigated in patients to be weaned from cardiopulmonary bypass (placebo-controlled trial). Under steady-state conditions, enoximone produced a substantial increase in cardiac index (20.6 +/- 1.7%), but no change in heart rate. The improvement in cardiac index with time until constant values were reached (6 h) was not directly paralleled by the plasma concentration of enoximone. Pharmacodynamically relevant concentrations were already present after 1 h of infusion (480 +/- 68 ng/ml) and comparable with the value determined after 6 h (442 +/- 37 ng/ml). After 18 h of infusion, plasma concentration had reached 742 +/- 47 ng/ml without a further improvement in cardiac function. The augmentation of stroke volume index (23.3 +/- 2.5%) occurred concomitantly with a decrease in systemic vascular resistance (-23.1 +/- 0.6%), obviously due to a decrease in diastolic arterial pressure (-12.0 +/- 3.8%). The pulmonary capillary wedge pressure remained unaffected. There was only a slight decrease in pulmonary vascular resistance (-9.3 +/- 3.2%). During both enoximone infusion and dopamine infusion, right atrial pressure increased (10.0 +/- 3.1 and 9.0 +/- 1.8%, respectively), in contrast to the untreated control group. This is contradictory to the drugs' described effect in patients suffering from congestive heart failure. At a concentration which would not normally cause cardiac acceleration, dopamine provided minor haemodynamic support in the period after cardiopulmonary bypass.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D E Birnbaum; J G Preuner; R Gieseke; D Trenk; E Jaehnchen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiology Volume: 77 Suppl 3 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1990 |
Date Detail:
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Created Date: 1991-02-12 Completed Date: 1991-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 34-41; discussion 62-7 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Rehabilitation Center, Bad Krozingen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Output
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drug effects Cardiopulmonary Bypass* Dopamine / therapeutic use* Enoximone Female Humans Imidazoles / therapeutic use* Male Middle Aged Phosphodiesterase Inhibitors / therapeutic use* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Phosphodiesterase Inhibitors; 77671-31-9/Enoximone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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