| Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss. | |
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MedLine Citation:
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PMID: 19100956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polycystic ovary syndrome (PCOS), thrombophilia, and hypofibrinolysis are associated with recurrent pregnancy loss (RPL) and spontaneous abortion (SAB). In 28 Caucasian women, 21 women with PCOS (4 with previous thrombosis, 18 with 1 SAB or more, and 20 with 1 coagulation disorder or more), and 7 women with coagulation disorders-thrombi, we speculated that prospective treatment with enoxaparin-metformin or enoxaparin alone would successfully and safely promote healthy live births compared with previous untreated pregnancies. In 21 women with PCOS, metformin (1.5-2.55 g/day) was given before and during pregnancy with concurrent enoxaparin (60 mg/day). Of 21 PCOS women, 19 women had 40 previous untreated pregnancies, 7 had live births (18%), 3 had elective abortions (ABs) (8%), and 30 had SABs (75%). On enoxaparin-metformin, these 19 women had 24 pregnancies, 20 live births (83%), and 4 SABs (17%); the SAB rate was 4.4-fold lower than previous untreated pregnancies (McNemar's s = 20.8, P < 0. 0001). Two women with PCOS without previous pregnancies, but with previous thrombosis, had 2 pregnancies on enoxaparin-metformin and 2 live births. Of the 7 women with coagulation disorders-thrombi, 4 had 15 previous pregnancies without enoxaparin, with 6 live births (40%), 8 SABs (53%), and 1 elective AB (7%). On enoxaparin, these 4 women had 4 pregnancies, with 4 (100%) live births (McNemar's s = 8.0, P = 0.005). The other 3 women with coagulation disorders-thrombi had 4 pregnancies on enoxaparin with 4 live births. No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin. Enoxaparin-metformin reduces pregnancy loss in women with PCOS-coagulation disorders and in women with coagulation disorders-thrombi. |
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Authors:
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Ganga Ramidi; Naseer Khan; Charles J Glueck; Ping Wang; Naila Goldenberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-04 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 153 ISSN: 1931-5244 ISO Abbreviation: Transl Res Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 33-43 Citation Subset: AIM; IM |
Affiliation:
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Cholesterol Center, Jewish Hospital, Cincinnati, OH 45229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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etiology,
prevention & control Abortion, Spontaneous / etiology, prevention & control* Adult Anticoagulants / therapeutic use* Blood Coagulation Disorders / drug therapy*, etiology Dose-Response Relationship, Drug Drug Therapy, Combination Embryo Loss / etiology, prevention & control Enoxaparin / therapeutic use* Female Humans Hypoglycemic Agents / therapeutic use* Live Birth Metformin / therapeutic use* Polycystic Ovary Syndrome / complications, drug therapy* Pregnancy Pregnancy Complications, Hematologic / drug therapy* Prospective Studies Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Enoxaparin; 0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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