| Enlargement of thermal ablation zone by the combination of ethanol injection and radiofrequency ablation in excised bovine liver. | |
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MedLine Citation:
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PMID: 14719103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of radiofrequency ablation (RFA) and RFA with concurrent ethanol injection (EI-RFA) was compared. RFA (3-cm-electrode) was applied to bovine liver using three types of RFA equipment; Radionics, RITA and Radio Therapeutics Corporation (RTC). For EI-RFA, 5 ml of 99.5% ethanol was injected around the electrode. A total number of 40 RFA and EI-RFA treatments were performed. We compared RFA with EI-RFA by examining the size, shape of ablation zone, treatment time, power, and needle tip temperature. Liver specimens were examined for pathological changes. EI-RFA produced a larger zone of ablation than RFA alone using Radionics and RITA (Radionics, 35.3+/-7.4 cm(3) vs 23.2+/-7.7 cm(3), p<0.05; RITA, 30.7+/-10.3 cm(3) vs 19.7+/-4.7 cm(3), p<0.05), corresponding to shortest diameters of coagulation zone (Radionics, 3.7+/-0.4 cm vs 3.0+/-0.4 cm, p<0.05; RITA, 3.8+/-0.4 cm vs 3.1+/-0.3 cm, p<0.01). However, a larger ablation zone was not seen with the RTC device. The ablated volume per energy and the ablated volume per current density administered were greater with EI-RFA than with RFA using Radionics (p<0.05). The shape of the ablated zone changed from ellipsoid to spherical with EI-RFA using Radionics. No pathological differences between RFA and EI-RFA samples were detected. For a given amount of energy and current administered, ethanol injection caused a better ablation effect, in terms of the size and shape of the ablated zone, than RFA with Radionics and RITA equipment. |
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Authors:
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Seishiro Watanabe; Kazutaka Kurokohchi; Tsutomu Masaki; Yoshiaki Miyauchi; Toshiharu Funaki; Hideyuki Inoue; Takashi Himoto; Yuko Kita; Naohito Uchida; Tetsuo Touge; Toshiaki Tatsukawa; Shigeki Kuriyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of oncology Volume: 24 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-13 Completed Date: 2004-08-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: Greece |
Other Details:
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Languages: eng Pagination: 279-84 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents, Local / pharmacology Catheter Ablation / methods* Cattle Electrodes Ethanol / pharmacology* Hot Temperature Liver / drug effects*, metabolism, pathology*, radiation effects* Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 64-17-5/Ethanol |
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