| Enkephalinase inhibitors: potential agents for the management of pain. | |
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MedLine Citation:
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PMID: 18855623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Management of acute and chronic pain has always been a key area of clinical research. Enkephalinase inhibitors (EIs) seem to be promising as therapeutic agents having antinociceptive action. They additionally possess anticraving, antidiarrhoeal and antidepressant actions. The antinociceptive action of EIs has been reported for over a decade however, their therapeutic potential is yet to be effectively explored. EIs may be broadly classified as endogenous and those that are obtained synthetically. Endogenous EIs include peptides like spinorphin and opiorphin. And compounds like RB 101, RB 120, RB 3007 constitute the synthetically obtained EIs. Endogenous and synthetic inhibitors enkephalin degrading enzymes have been studied in vivo using standard animal models. The potential EI targets appear to be APN (Aminopeptidase N), NEP (Neutral endopeptidase), DPP-III (Dipeptidyl peptidase). EIs possess the advantage that they lack the opioid side effects. This article reviews the mechanisms by which EIs act and elucidates the pathways involved. |
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Authors:
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V Thanawala; V J Kadam; R Ghosh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug targets Volume: 9 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 887-94 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Bharati Vidyapeeth's College of Pharmacy, Sector 8, CBD Belapur, Navi Mumbai, Maharashtra, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Management Drug Delivery Systems / methods Humans Neprilysin / antagonists & inhibitors*, metabolism Pain / drug therapy*, enzymology* Pain Measurement / drug effects, methods Protease Inhibitors / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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