Document Detail


Enkephalin degradating enzymes in pheochromocytoma patients.
MedLine Citation:
PMID:  12469178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenal gland as a major source of enkephalins on the periphery can be affected by a rare adrenal gland tumor, adrenal pheochromocytoma. It has been demonstrated that this tumor might be associated with altered concentration of enkephalin-like peptides. The effect of these peptides can be either prolonged or abbreviated by two neutrophil membrane bound enzymes; aminopeptidase N (APN) and neutral endopeptidase (NEP). We assumed that altered enkephalin level in pheochromocytoma patients (but not in patients with non-functional adenomas or tumors of different origin) might result in differently regulated APN and/or NEP activity. We measured APN and NEP activity on surface of neutrophils, level of lipid peroxidation (LPO) in plasma and enkephalin concentration in plasma in patients with pheochromocytomas, non-functional adenomas, malignant renal tumors and healthy controls. Catheholamines and vanyllmandelic acid (VMA) were measured in 24-h urine of pheochromocytoma patients. NEP and APN activity on neutrophils from all pheochromocytoma patients was significantly increased as compared with healthy controls, non-functional adenomas and malignant renal tumors. In all pheochromocytoma patients NEP activity was reduced almost to the control level after surgery. At the same time APN activity was in some patients up- and in others down-regulated. In comparison, elevated levels of cateholamines and VMA were found after multiple determinations in 6 out of 10 pheochromocytoma patients. Although preliminary, this study has shown specifically and consistently up-regulated NEP activity on neutrophils from pheochromocytoma patients, and uniformly decreased NEP activity in these patients after adrenalectomy.
Authors:
Tihomir Balog; Tatjana Marotti; Visnja Sverko; Miljenko Marotti; Ivan Krolo; Boris Rocic; Nikola Karapanda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  10     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2002-12-06     Completed Date:  2003-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Affiliation:
Institute Ruder Boskovic, Department of Molecular Medicine, University of Zagreb, Croatia. balog@rudjer.irb.hr
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MeSH Terms
Descriptor/Qualifier:
Adenoma / enzymology,  pathology
Adrenal Gland Neoplasms / enzymology*,  pathology
Antigens, CD13 / blood*
Case-Control Studies
Catecholamines / urine
Down-Regulation
Enkephalin, Methionine / blood
Enkephalins / blood*
Humans
Lipid Peroxidation
Neprilysin / blood*
Neutrophils / metabolism
Pheochromocytoma / enzymology*,  pathology
Thiobarbituric Acid Reactive Substances / metabolism
Up-Regulation
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Enkephalins; 0/Thiobarbituric Acid Reactive Substances; 58569-55-4/Enkephalin, Methionine; EC 3.4.11.2/Antigens, CD13; EC 3.4.24.11/Neprilysin

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