Document Detail


Enkephalin surges in dorsal neostriatum as a signal to eat.
MedLine Citation:
PMID:  23000149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Compulsive overconsumption of reward characterizes disorders ranging from binge eating to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial quadrant of dorsal neostriatum contribute to generating intense consumption of palatable food. In ventral striatum, mu opioid circuitry contributes an important component of motivation to consume reward. In dorsal neostriatum, mu opioid receptors are concentrated within striosomes that receive inputs from limbic regions of prefrontal cortex. We employed advanced opioid microdialysis techniques that allow detection of extracellular enkephalin levels. Endogenous >150% enkephalin surges in anterior dorsomedial neostriatum were triggered as rats began to consume palatable chocolates. In contrast, dynorphin levels remained unchanged. Furthermore, a causal role for mu opioid stimulation in overconsumption was demonstrated by observations that microinjection in the same anterior dorsomedial quadrant of a mu receptor agonist ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DAMGO) generated intense >250% increases in intake of palatable sweet food (without altering hedonic impact of sweet tastes). Mapping by "Fos plume" methods confirmed the hyperphagic effect to be anatomically localized to the anteromedial quadrant of the dorsal neostriatum, whereas other quadrants were relatively ineffective. These findings reveal that opioid signals in anteromedial dorsal neostriatum are able to code and cause motivation to consume sensory reward.
Authors:
Alexandra G DiFeliceantonio; Omar S Mabrouk; Robert T Kennedy; Kent C Berridge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-20
Journal Detail:
Title:  Current biology : CB     Volume:  22     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-05-01     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1918-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cacao
Dynorphins / analysis
Eating / drug effects,  physiology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology
Enkephalins / metabolism*,  pharmacology
Feeding Behavior* / physiology
Hyperphagia*
Neostriatum / drug effects,  metabolism*
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu / agonists,  metabolism*
Signal Transduction
Grant Support
ID/Acronym/Agency:
DA007267/DA/NIDA NIH HHS; DA015188/DA/NIDA NIH HHS; DA07268/DA/NIDA NIH HHS; MH63649/MH/NIMH NIH HHS; R01 DA015188/DA/NIDA NIH HHS; R01 MH063649/MH/NIMH NIH HHS; R37 EB003320/EB/NIBIB NIH HHS; R37 EB003320/EB/NIBIB NIH HHS; T32 DA007267/DA/NIDA NIH HHS; T32 DA007268/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Enkephalins; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 74913-18-1/Dynorphins
Comments/Corrections
Comment In:
Curr Biol. 2012 Oct 23;22(20):R878-80   [PMID:  23098597 ]

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